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Titolo:
The COE Collier/Olf1/EBFC transcription factors: structural conservation and diversity of developmental functions
Autore:
Dubois, L; Vincent, A;
Indirizzi:
Univ Toulouse 3, Ctr Dev Biol, CNRS, UMR 5547, F-31062 Toulouse 04, FranceUniv Toulouse 3 Toulouse France 04 UMR 5547, F-31062 Toulouse 04, France
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 108, anno: 2001,
pagine: 3 - 12
SICI:
0925-4773(200110)108:1-2<3:TCCTFS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL FACTOR; CAENORHABDITIS-ELEGANS; DNA-BINDING; PRIMARY NEUROGENESIS; NEURONAL DEVELOPMENT; GENE-EXPRESSION; FINGER PROTEIN; FACTOR COLLIER; DROSOPHILA; DIFFERENTIATION;
Keywords:
COE factors; ebf; col; olf-1; unc-3; neurogenesis; notch signalling; transcription factors; evolutionary conservation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Dubois, L Natl Inst Med Res, Div Mammalian Dev, The Ridgeway,Mill Hill, London NW7 1AA, England Natl Inst Med Res The Ridgeway,Mill Hill London England NW7 1AA
Citazione:
L. Dubois e A. Vincent, "The COE Collier/Olf1/EBFC transcription factors: structural conservation and diversity of developmental functions", MECH DEVEL, 108(1-2), 2001, pp. 3-12

Abstract

One major conclusion of studies in Developmental Biology during the last two decades is that, despite profound anatomical differences, the building of vertebrate and arthropod bodies relies on the same fundamental molecular networks, including conserved cell signalling and transcription-regulatory cascades. Rodent Early B-Cell Factor/Olfactory-1 and Drosophila Collier belong to a recently defined, novel family of transcription factors, the Collier/Olf1/EBF (COE) proteins which have a unique DNA-binding domain. Early investigations revealed that, despite their high degree of sequence identity,the different vertebrate and invertebrate COE proteins play a variety of developmental roles. We review here the current evidence for this diversity of COE functions, including in the specification and differentiation of various neuronal populations. We also discuss the existence of an evolutionarily conserved pathway linking Notch signalling and COE regulatory functions in various developmental decisions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 04:07:01