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Titolo:
Regulated gene expression dictates enamel structure and tooth function
Autore:
Paine, ML; White, SN; Luo, W; Fong, H; Sarikaya, M; Snead, ML;
Indirizzi:
Univ So Calif, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 ol Biol, Los Angeles, CA 90033 USA Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90095 USA Univ Calif LosAngeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 at Sci & Engn, Seattle, WA 98195 USA
Titolo Testata:
MATRIX BIOLOGY
fascicolo: 5-6, volume: 20, anno: 2001,
pagine: 273 - 292
SICI:
0945-053X(200109)20:5-6<273:RGEDES>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED AMELOGENESIS IMPERFECTA; EPITHELIAL-MESENCHYMAL INTERACTIONS; DYNAMIC LIGHT-SCATTERING; DENTAL ENAMEL; MECHANICAL-PROPERTIES; PROTEIN INTERACTIONS; MATRIX PROTEINS; HUMAN-TEETH; DENTINOENAMEL JUNCTION; RECOMBINANT AMELOGENIN;
Keywords:
amelogenin; structural hierarchy; protein-protein interactions; transgenic mouse; biomimetics; fracture toughness; biomineralization; dentine; dentine enamel junction;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Paine, ML Univ So Calif, Ctr Craniofacial Mol Biol, 2250 Alcazar St, Los Angeles, CA90033 USA Univ So Calif 2250 Alcazar St Los Angeles CA USA 90033 90033 USA
Citazione:
M.L. Paine et al., "Regulated gene expression dictates enamel structure and tooth function", MATRIX BIOL, 20(5-6), 2001, pp. 273-292

Abstract

Enamel is a complex bioceramic tissue. In its final form, enamel is a reflection of the unique molecular and cellular activities occurring during organogenesis. From the ectodermal origins of ameloblasts, their gene activityand protein expression profiles exist for the sole purpose of producing a mineralized shell, almost entirely devoid of protein, deposited over the 'bone-like' dentine. The interface between enamel and dentine is referred to as the dentine enamel junction and it is also unique in its biology. This review article is narrow in its scope. We restrict our review to selected advances in our understanding of the genetic, molecular and structural aspects of enamel biology. We present a model of enamel formation that relates gene expression to the assembly of an extracellular protein matrix that in turn controls the structural hierarchy and mechanical aspects of enamel and the tooth organ. (C) 2001 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:01:11