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Titolo:
Comparative bioavailability of dietary alpha-linolenic and docosahexaenoicacids in the growing rat
Autore:
Poumes-Ballihaut, C; Langelier, B; Houlier, F; Alessandri, JM; Durand, G; Latge, C; Guesnet, P;
Indirizzi:
INRA, CRJ, Lab Nutr & Securite Alimentaire, F-78352 Jouy En Josas, France INRA Jouy En Josas France F-78352 entaire, F-78352 Jouy En Josas, France Bledina Sa, Grp Danone, Villefranche Sur Saone, France Bledina Sa Villefranche Sur Saone France Villefranche Sur Saone, France
Titolo Testata:
LIPIDS
fascicolo: 8, volume: 36, anno: 2001,
pagine: 793 - 800
SICI:
0024-4201(200108)36:8<793:CBODAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYUNSATURATED FATTY-ACIDS; EICOSAPENTAENOIC ACID; ADIPOSE-TISSUE; BETA-OXIDATION; LIVER CELLS; FISH-OIL; DEFICIENCY; RETROCONVERSION; METABOLISM; INCREASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Poumes-Ballihaut, C INRA, CRJ, Lab Nutr & Securite Alimentaire, F-78352 Jouy En Josas, France INRA Jouy En Josas France F-78352 y En Josas, France
Citazione:
C. Poumes-Ballihaut et al., "Comparative bioavailability of dietary alpha-linolenic and docosahexaenoicacids in the growing rat", LIPIDS, 36(8), 2001, pp. 793-800

Abstract

Animal and human studies have indicated that developing mammals fed only alpha -linolenic acid (18:3n-3) have lower docosahexaenoic acid (22:6n-3) content in brain and tissue phospholipids when compared with mammals fed 18:3n-3 plus 22:6n-3. The aim of this study was to test the hypothesis that lowbioavailability of dietary 18:3n-3 to be converted to 22-6n-3 could partlyexplain this difference in fatty acid accretion. For that purpose, we determined the partitioning of dietary 18:3n-3 and 22:6n-3 between total n-3 fatty acid body accumulation, excretion, and disappearance (difference between the intake and the sum of total n-3 fatty acids accumulated and excreted). This was assessed using the quantitative method of whole-body fatty acid balance in growing rats fed the same amount of a 5% fat diet supplying either 18:3n-3 or 22:6n-3 at a level of 0.45% of dietary energy (i.e., 200 mg/100 g diet). We found that 58.9% of the total amount of 18:3n-3 ingested disappeared, 0.4% was excreted in feces, 21.2% accumulated as 18:3n-3 (50% in total fats and 46% in the carcass-skin compartment), and 17.2% accumulated as long-chain derivatives (14% as 22:6n-3 and 3.2% as 20:5n-3 + 22:5n-3). Similar results were obtained from the docosahexaenoate balance (as % of thetotal amount ingested): disappearance, 64.5%; excretion, 0.5%; total accumulation., 35% with 30.1 % as 22:6n-3. Thus, rats fed docosahexaenoate accumulated a twofold higher amount of 22:6n-3, which was mainly deposited in the carcass-skin compartment (68%). Similar proportions of disappearance of dietary 18:3n-3 and 22:6n-3 lead us to speculate that these two n-3 polyunsaturated fatty acids were beta -oxidized in the same amount.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:49:42