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Titolo:
Aminoglycoside ototoxicity: A human temporal bone study
Autore:
Hinojosa, R; Nelson, EG; Lerner, SA; Redleaf, MI; Schramm, DR;
Indirizzi:
Univ Chicago, Med Ctr, Sect Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Head & Neck Surg, Chicago, IL 60637 USA Wayne State Univ, Harper Hosp, Sch Med, Div Infect Dis, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 v Infect Dis, Detroit, MI 48201 USA
Titolo Testata:
LARYNGOSCOPE
fascicolo: 10, volume: 111, anno: 2001,
pagine: 1797 - 1805
SICI:
0023-852X(200110)111:10<1797:AOAHTB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTOPATHOLOGY; GENTAMICIN; COCHLEAE;
Keywords:
aminoglycoside ototoxicity; human temporal bone histopathology; organ of Corti; spiral ganglion cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hinojosa, R Univ Chicago, Med Ctr, Sect Otolaryngol Head & Neck Surg, 5841S Maryland Ave,MC 1035, Chicago, IL 60637 USA Univ Chicago 5841 S MarylandAve,MC 1035 Chicago IL USA 60637
Citazione:
R. Hinojosa et al., "Aminoglycoside ototoxicity: A human temporal bone study", LARYNGOSCOP, 111(10), 2001, pp. 1797-1805

Abstract

Objective. Hearing loss after aminoglycoside administration has been thought to result primarily from. hair cell injury. The purpose of the study wasto determine the potential for direct injury of spiral ganglion cells and hair cells in cases of documented human aminoglycoside ototoxicity. Study Design: Retrospective case review. Methods: The clinical course of two individuals with aminoglycoside ototoxicity are documented, including the details of administration of tobramycin and other ototoxic medication and serial audiograms. The temporal bones were processed, and the cochlear elements quantified. Results. Histopathological study of the temporal bones from the individuals in the study demonstrated reduction of both ganglion cell and hair cell populations. Spiral ganglion cell loss was not necessarily subadjacent to areas of hair cell loss in cases of aminoglycoside ototoxicity. Instead, spiral ganglion cell reduction may be present in segments of the cochlea with normal-appearing hair cells. Conclusions: The study suggests that aminoglycoside antibiotics can injure spiral ganglion cells directly, as well as hair cells. Thus, the characteristic hearing loss of ototoxicity can result from degeneration of either cochlear element.

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Documento generato il 28/05/20 alle ore 10:53:27