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Titolo:
Diagnosis, treatment and results of malignant skull base tumours.
Autore:
Volter, C; Baier, G; Hoppe, F; Schwager, K; Helm, J;
Indirizzi:
Univ Wurzburg, HNO Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 O Klin, D-97080 Wurzburg, Germany
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 9, volume: 80, anno: 2001,
pagine: 512 - 516
SICI:
1615-0007(200109)80:9<512:DTAROM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
GER
Soggetto:
CRANIOFACIAL RESECTION; SINUS-CANCER; TUMORS; SURGERY; COMPLICATIONS; SURVIVAL;
Keywords:
skull base malignomas; diagnosis; therapy; results;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Volter, C Univ Wurzburg, HNO Klin, Josef Schneider Str 11, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080 y
Citazione:
C. Volter et al., "Diagnosis, treatment and results of malignant skull base tumours.", LARY RH OTO, 80(9), 2001, pp. 512-516

Abstract

Background: Malignant tumours of the cranial base are rare and present usually in advanced tumour stage due to the lack of early clinical symptoms. Patients and Methods: Sixty patients with malignant tumours infiltrating theskull base were treated at the Department of Otorhinolaryngology Head and Neck Surgery, University of Wurzburg between 1987 and 1999. Most of the tumours (n = 51) originated from the nose or paranasal sinuses, the epipharynx, the outer ear canal or the middle ear. Seven tumours were malignant braintumours; infiltrating the bony structures of the skull base or originated from the cranial base itself. Two patients suffered from metastases of an adenocarcinoma of the prostata. The histological diagnosis was confirmed in 53 patients preoperatively and in seven patients during tumour resection. Squamous cell carcinoma (n = 24), adenocarcinoma (n = 10) and sarcoma (n = 7) were the most common histologies found. Results: A radical en bloc resection of the tumour was only possible in 26 out of 60 cases. A surgical tumour reduction with postoperative radiation therapy was performed in seven patients as a palliative approach. Eight patients underwent a combined radio- and chemotherapy according to the histological diagnosis. Primary radiotherapy was the treatment of choice in eleven patients, where the tumours were located in the central area of the cranial base. Palliative radiotherapy orsolely medical pain control were applied to eight patients who presented either with distant metastases or an advanced tumour growth. The mean postoperative survival following radical surgery was 48 months and after primary radiotherapy 27 months. Discussion: A statistical analysis of the results is not applicable due to the great variety of the disease concerning the histological diagnosis, the tumour size and the location as well as the small number of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:52:18