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Titolo:
CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin
Autore:
Hausmann, J; Schamel, K; Staeheli, P;
Indirizzi:
Univ Freiburg, Inst Med Mikrobiol & Hyg, Dept Virol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 Virol, D-79104 Freiburg, Germany
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 21, volume: 75, anno: 2001,
pagine: 10460 - 10466
SICI:
0022-538X(200111)75:21<10460:CTLMBD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MOUSE HEPATITIS-VIRUS; CLASS-I; DEFICIENT MICE; IFN-GAMMA; INDUCED DEMYELINATION; ANTIGEN EXPRESSION; MULTIPLE-SCLEROSIS; INFECTED RATS; CELL-DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Hausmann, J Univ Freiburg, Inst Med Mikrobiol & Hyg, Dept Virol, Hermann Herder Str 11, D-79104 Freiburg, Germany Univ Freiburg Hermann Herder Str 11Freiburg Germany D-79104
Citazione:
J. Hausmann et al., "CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin", J VIROLOGY, 75(21), 2001, pp. 10460-10466

Abstract

Perforin-mediated lysis of target cells is the major antiviral effector mechanism of CD8(+) T lymphocytes. We have analyzed the role of perforin in amouse model for CD8(+) T-cell-mediated central nervous system (CNS) immunopathology induced by Borna disease virus. When a defective perforin gene was introduced into the genetic background of the Borna disease-susceptible mouse strain MRL, the resulting perforin-deficient mice developed strong neurological disease in response to infection indistinguishable from that of their perforin-expressing littermates. The onset of disease was slightly delayed. Brains of diseased perforin-deficient mice showed similar amounts anda similar distribution of CDS' T cells as wild-type animals. Perforin deficiency had no impact on the kinetics of viral spread through the CNS. Unlike brain lymphocytes from diseased wild-type mice, lymphocytes from perforin-deficient MRL mice showed no in vitro cytolytic activity towards target cells expressing the nucleoprotein of Borna disease virus. Taken together, these results demonstrate that CD8(+) T cells mediate Borna disease independent of perforin. They further suggest that the pathogenic potential of CNS-infiltrating CD8(+) T cells does not primarily reside in their lytic activity but rather in other functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:22:11