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Titolo:
Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues
Autore:
Maeda, S; Mizuno, T; Yamashita, K; Kurata, K; Masuda, K; Ohno, K; Tsujimoto, H;
Indirizzi:
Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 rnal Med, Bunkyo Ku, Tokyo 1138657, Japan Hitachi Chem Co Ltd, Pharmaceut Res Lab, Hitachi, Ibaraki 3178555, Japan Hitachi Chem Co Ltd Hitachi Ibaraki Japan 3178555 Ibaraki 3178555, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 9, volume: 63, anno: 2001,
pagine: 1035 - 1038
SICI:
0916-7250(200109)63:9<1035:MCOCTA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; ASTHMA;
Keywords:
canine; cDNA cloning; thymus and activation-regulated chemokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Maeda, S Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan Univ Tokyo 1-1-1 Yayoi Tokyo Japan1138657 Tokyo 1138657, Japan
Citazione:
S. Maeda et al., "Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues", J VET MED S, 63(9), 2001, pp. 1035-1038

Abstract

Thymus and activation-regulated chemokine (TARC) is known as a functional ligand for CC chemokine receptor 4 (CCR4), which is selectively expressed on Th2 lymphocytes and induces selective migration of the cells to allergic lesions. In this study, we cloned canine TARC cDNA from canine thymus by RT-PCR with rapid amplification of cDNA ends (RACE) method. The canine TARC clone contained a full-length open reading frame encoding 99 amino acids andincluded four cysteine residues characteristic to CC chemokine family. Thecanine TARC cDNA showed 77.5%, 67.4%, and 68.5% amino acid sequence similarity with human, mouse and rat homologues, respectively. Expression of TARCmRNA was detected not only in thymus but also in spleen, lymph node, lung and heart of the various normal dog tissues examined. TARC cDNA clone obtained in this study will be useful for further investigation on allergic diseases in dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:35:23