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Titolo:
Gender-based profiles of developmental immunotoxicity to lead in the rat: Assessment in juveniles and adults
Autore:
Bunn, TL; Parsons, PJ; Kao, E; Dietert, RR;
Indirizzi:
Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USACornell Univ Ithaca NY USA 14853 icrobiol & Immunol, Ithaca, NY 14853 USA Cornell Univ, Inst Comparat & Environm Toxicol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 & Environm Toxicol, Ithaca, NY 14853 USA New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA New York State Dept Hlth Albany NY USA th, Wadsworth Ctr, Albany, NY USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 3, volume: 64, anno: 2001,
pagine: 223 - 240
SICI:
1528-7394(20011012)64:3<223:GPODIT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; INVARIANT CHAIN EXPRESSION; BLOOD MONONUCLEAR-CELLS; PRODUCTION IN-VITRO; REPRODUCTIVE TOXICITY; IA EXPRESSION; EXPOSURE; MICE; IMMUNOSUPPRESSION; INTOXICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Dietert, RR Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 mmunol, Ithaca, NY 14853 USA
Citazione:
T.L. Bunn et al., "Gender-based profiles of developmental immunotoxicity to lead in the rat: Assessment in juveniles and adults", J TOX E H A, 64(3), 2001, pp. 223-240

Abstract

Gender-based differences in immunotoxicity induced by the heavy metal lead(Pb) have been observed both in the juvenile chicken and the adult rat following low-level exposure during embryonic development, To better define the gender-based differences, as related to dose following In utero exposure to Pb, potential differential sensitivities were examined after exposure ofF 344 rats to low concentrations of Pb (0, 50, 700, or 250 ppm Pb) ad libitum throughout gestation. Immune assessment was performed in juveniles (5 wk old) and young adults (13 wk old). At the highest (250 ppm) Pb concentration examined, the delayed-type hypersensitivity (DTH) response was depressed in females relative to gender-matched controls at both ages; relative spleen weights and relative neutrophil numbers were increased while relative and absolute monocyte numbers and relative basophil numbers were decreased at 13 but not 5 wk of age. In contrast, 250 ppm Pb-treated males did not differ in these endpoints. With in utero exposure to 100 ppm Pb, 13-wk-old females again had decreased relative and absolute monocyte numbers and increased relative neutrophil numbers, although the DTH response was unchanged. Males (with 100 ppm Pb) had increased relative neutrophil numbers, decreased relative lymphocytes, and transiently increased nitrite production seen at 5, but not 13, wk of age. After gestational exposure to 50 ppm Ph, minimal immunotoxic effects were observed in either males or females at either developmental age assessed. These results suggest that differential gender-based immunotoxicity profiles exist after gestational Ph exposure depending on the concentration of Pb administered to the dam. In utero exposure of dams to 250 ppm Pb results in more profound immunotoxicity in females than males, Males are not more sensitive to lower concentrations of Pb than females. Since the 50 ppm exposure produced minimal changes, these data may provide information to establish a no-observed-adverse-effect level (NOAEL) for in utero exposure to Pb. Additionally, white most effects were evident at bothjuvenile and adult ages, some changes were not fully evident until measured in the adult. Most changes were persistent with only one exception (male nitrite levels at 100 ppm).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 02:25:11