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Titolo:
Antioxidant status and lipid peroxidation in colorectal cancer
Autore:
Skrzydlewska, E; Stankiewicz, A; Sulkowska, M; Sulkowski, S; Kasacka, I;
Indirizzi:
Med Acad Bialystok, Dept Analyt Chem, PL-15230 Bialystok, Poland Med Acad Bialystok Bialystok Poland PL-15230 PL-15230 Bialystok, Poland Med Acad Bialystok, Dept Anat Patol, Bialystok, Poland Med Acad BialystokBialystok Poland Dept Anat Patol, Bialystok, Poland Med Acad Bialystok, Dept Histol & Embryol, Bialystok, Poland Med Acad Bialystok Bialystok Poland Histol & Embryol, Bialystok, Poland
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 3, volume: 64, anno: 2001,
pagine: 213 - 222
SICI:
1528-7394(20011012)64:3<213:ASALPI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; OXIDATIVE STRESS; GLUTATHIONE-PEROXIDASE; ALPHA-TOCOPHEROL; REACTIVE OXYGEN; HEPATOMA-CELLS; FREE-RADICALS; COLON-CANCER; LUNG-CANCER; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Skrzydlewska, E Med Acad Bialystok, Dept Analyt Chem, POB 14, PL-15230 Bialystok, Poland Med Acad Bialystok POB 14 Bialystok Poland PL-15230 oland
Citazione:
E. Skrzydlewska et al., "Antioxidant status and lipid peroxidation in colorectal cancer", J TOX E H A, 64(3), 2001, pp. 213-222

Abstract

Colon carcinogenesis is a multistep process where oxygen radicals were found to enhance carcinogenesis at all stages: initiation, promotion, and progression. Since insufficient capacity of protective antioxidant system can result in cancer, the aim of this study was to examine the activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, andglutathione reductase) and the levels of reduced glutathione, vitamin C, and vitamin E. The lipid peroxidation products were also determined by measuring malondialdehyde and 4-hydroxynonenal levels in colorectal cancer tissue collected from 55 patients. In these cases the activity of superoxide dismutase, glutathione peroxidase, and glutathione reductase was significantlyincreased while the activity of catalase was significantly decreased in cancer tissue. However, the level of nonenzymatic antioxidant parameters (glutathione, vitamin C, and vitamin E) was significantly decreased in cancer tissue. Further lipid peroxidation was enhanced during cancer development, manifested by a significant increase in malondialdehyde and 4-hydroxynonenallevels. The obtained results indicate significant changes in antioxidant capacity of colorectal cancer tissues, which lead to enhanced action of oxygen radicals, resulting in lipid peroxidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:45:57