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Titolo:
Impaired novelty P3 potentials in multiple system atrophy - correlation with orthostatic hypotension
Autore:
Deguchi, K; Takeuchi, H; Sasaki, I; Tsukaguchi, M; Touge, T; Nishioka, M;
Indirizzi:
Kagawa Med Univ, Dept Internal Med 3, Miki, Kagawa 7610793, Japan Kagawa Med Univ Miki Kagawa Japan 7610793 3, Miki, Kagawa 7610793, Japan Kagawa Med Univ, Dept Hlth Sci, Miki, Kagawa 7610793, Japan Kagawa Med Univ Miki Kagawa Japan 7610793 ci, Miki, Kagawa 7610793, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 190, anno: 2001,
pagine: 61 - 67
SICI:
0022-510X(20010915)190:1-2<61:INPPIM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; FRONTAL-LOBE DYSFUNCTION; CEREBRAL BLOOD-FLOW; NEUROPSYCHOLOGICAL FOLLOW-UP; EVENT-RELATED POTENTIALS; F-18 DOPA UPTAKE; PARKINSONS-DISEASE; STRIATONIGRAL DEGENERATION; INTRACEREBRAL POTENTIALS; AUTONOMIC DYSFUNCTION;
Keywords:
event-related potential (ERP); somatosensory; novelty P3; frontal lobe; orthostatic hypotension; multiple system atrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Deguchi, K Kagawa Med Univ, Dept Internal Med 3, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan Kagawa Med Univ 1750-1 Ikenobe Miki Kagawa Japan 7610793 Japan
Citazione:
K. Deguchi et al., "Impaired novelty P3 potentials in multiple system atrophy - correlation with orthostatic hypotension", J NEUR SCI, 190(1-2), 2001, pp. 61-67

Abstract

Although neuropsychological tests demonstrate frontal lobe dysfunction in multiple system atrophy (MSA), assessment of frontal function using event-related brain potentials (ERPs) has not been sufficiently performed in MSA. The correlation between frontal lobe dysfunction and orthostatic hypotension (OH), which is known to cause frontal hypoperfusion, remains unclear. Ourobjectives were to assess frontal lobe dysfunction in MSA patients using ERPs and to elucidate the relevance of OH to changes in ERPs. Nine consecutive patients with MSA and nine age- and gender-matched healthy controls werecompared by performance in the Wisconsin Card Sorting Test (WCST) and somatosensory ERPs to target and novel stimuli, namely, parietal maximal P3 (target P3) and fronto-central P3 (novelty P3), respectively. The correlation between novelty P3 and OH was evaluated in the MSA group. The MSA group showed a poorer performance in categories achieved (CA), total errors (TE) andperseverative errors by Nelson's (PEN) method in the WCST compared with the control group (CA and PEN: p < 0.01; TE: p < 0.02). Novelty and target P3s in the MSA group showed significantly prolonged latency (novelty: p < 0.05; target: p < 0.01) and reduced amplitude (novelty: p < 0.02; target: p < 0.01) compared with the control group. There was a significant negative correlation between novelty P3 latency and a drop in systolic blood pressure (r = 0.76; p < 0.02). Abnormalities of novelty P3 in the MSA group might reflect frontal lobe dysfunction, namely failure of attentional set-shifting, that was identified by the WCST. OH may play a role in the development of frontal lobe dysfunction in MSA. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:15:00