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Titolo:
Elevated bioactive prolactin levels in systemic lupus erythematosus - Association with disease activity
Autore:
Pacilio, M; Migliaresi, S; Meli, R; Ambrosone, L; Bigliardo, B; Di Carlo, R;
Indirizzi:
Univ Naples Federico II, Dept Expt Pharmacol, Naples, Italy Univ Naples Federico II Naples Italy Dept Expt Pharmacol, Naples, Italy Univ Naples 2, Div Rheumatol, Inst Clin Med, Naples, Italy Univ Naples 2 Naples Italy Div Rheumatol, Inst Clin Med, Naples, Italy
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 10, volume: 28, anno: 2001,
pagine: 2216 - 2221
SICI:
0315-162X(200110)28:10<2216:EBPLIS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOMA CELL BIOASSAY; SERUM PROLACTIN; GROWTH-HORMONE; LACTOGENIC HORMONES; PITUITARY-HORMONE; HYPERPROLACTINEMIA; RADIOIMMUNOASSAY; BROMOCRIPTINE; IMMUNE; AUTOANTIBODIES;
Keywords:
bioactive prolactin; immunoactive prolactin; systemic lupus erythematosus; disease activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Di Carlo, R Univ Naples, Dept Expt Pharmacol, Via Domenico Montesano 49, I-80131 Naples, Italy Univ Naples Via Domenico Montesano 49 Naples Italy I-80131 ly
Citazione:
M. Pacilio et al., "Elevated bioactive prolactin levels in systemic lupus erythematosus - Association with disease activity", J RHEUMATOL, 28(10), 2001, pp. 2216-2221

Abstract

Objective. To assess the possibility that prolactin (PRL) is involved in the pathogenesis of systemic lupus erythematosus (SLE). Methods. We determined serum PRL levels in 122 serum samples from 78 unselected patients with SLE (73 women, 5 men, age range 16-71 yrs). Disease activity was defined according to Lupus Activity Criteria Count (LACC) and scored by Systemic Lupus Disease Activity Index (SLEDAI). Serum PRL concentrations were determined by immunoradiometric assay (IRMA) and by biological assay (BA) that evaluates Nb2 lymphoma cell proliferation. Results. Hyperprolactinemia (> 20 ng/ml) was found in 21 patients (26.9%) by IRMA and in 31 (39.7%) by BA. A significant correlation between IRMA andBA PRL levels was found (r(s) 0.46, p < 0.001). According to LACC, SLE wasactive in 29 patients and inactive in 49. In those with active disease median PRL levels were higher both by IRMA (18.5 ng/ml, range 2.2-51.2 vs 10.6ng/ml, range 3.9-29.6; p < 0.001) and BA (21.0 ng/ml, range 12.4-84 vs 14.9 ng/ml, range 4.2-46.1; p <less than> 0.001). Hyperprolactinemia was associated with active disease in 13/21 patients (61.9%) by IRMA and in 18/31 (58.1%) by BA (p < 0.01). SLEDAI scores correlated with PRL levels both by IRMA (r(s) 0.5, p < 0.001) and BA (r(s) 0.41, p < 0.02). A followup analysis on serum samples from 44 patients seen again after 6-8 mo confirmed the above results. There was no difference in the rate of different clinical manifestations in hyperprolactinemia and normoprolactinemic subjects, apart fromthe increased prevalence of malar rash and central nervous system manifestations in the patients with hyperprolactinemia (p < 0.03 and p < 0.01, respectively). Conclusion. Hyperprolactinemia was frequently detected in patients with SLE by IRMA and by BA and was associated with disease activity. Our Findings suggest that PRL may play a role in the pathogenesis of SLE.

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Documento generato il 04/07/20 alle ore 20:50:10