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Titolo:
Postreceptor pathways for signal transduction in depression and bipolar disorder
Autore:
Young, LT;
Indirizzi:
McMaster Univ, Dept Psychiat, Hamilton, ON, Canada McMaster Univ HamiltonON Canada iv, Dept Psychiat, Hamilton, ON, Canada McMaster Univ, Reg Mood Disorders Program, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada Disorders Program, Hamilton, ON, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
, volume: 26, anno: 2001, supplemento:, S
pagine: S17 - S22
SICI:
1180-4882(2001)26:<S17:PPFSTI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSION; CHRONIC LITHIUM; VALPROATE TREATMENT; TEMPORAL CORTEX; CEREBRAL-CORTEX; MOOD DISORDERS; EXPRESSION; PROTEINS; BINDING; SUICIDE;
Keywords:
antidepressive agents; bipolar disorder; brain-derived neurotrophic factor; cyclic AMP; depressive disorder; DNA-binding protein; cyclic AMP-responsive; G protein; stimulatory Gs; lithium; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Young, LT Hamilton Psychiat Hosp, Mood Disorders Program, 100 W 5th St, Hamilton, ONL8N 3K7, Canada Hamilton Psychiat Hosp 100 W 5th St Hamilton ON Canada L8N 3K7 a
Citazione:
L.T. Young, "Postreceptor pathways for signal transduction in depression and bipolar disorder", J PSYCH NEU, 26, 2001, pp. S17-S22

Abstract

Study of the norepinephrine pathway has elucidated the pathophysiology of depression and bipolar disorder. Various elements along this pathway, including adrenoreceptors, G proteins, cyclic adenosine monophosphate (AMP), cyclic AMP regulatory element binding protein and brain-derived neurotrophic factor, have been identified as potential targets for antidepressants and mood-stabilizing drugs. The results of a wide range of research in this area,along with the hypotheses now under investigation, are summarized in this paper.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 11:06:17