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Titolo:
Crosstalk between the norepinephrine and serotonin systems and its role inthe antidepressant response
Autore:
Blier, P;
Indirizzi:
Univ Florida, Inst Brain, Dept Psychiat & Neurosci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Neurosci, Gainesville, FL 32610 USA
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
, volume: 26, anno: 2001, supplemento:, S
pagine: S3 - S10
SICI:
1180-4882(2001)26:<S3:CBTNAS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT DORSAL HIPPOCAMPUS; LOCUS-COERULEUS; ELECTROPHYSIOLOGICAL CHARACTERIZATION; 5-HYDROXYTRYPTAMINE SYSTEM; ANTAGONIST MIRTAZAPINE; NORADRENERGIC NEURONS; MAJOR DEPRESSION; FIRING ACTIVITY; BRAIN; NEUROTRANSMISSION;
Keywords:
adrenergic alpha-antagonist; adrenergic beta-antagonist; adrenergic reuptake inhibitors; depressive disorder; dopamine; mood disorders; norepinephrine; serotonin; serotonin uptake inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Blier, P Univ Florida, Dept Psychiat, POB 100256, Gainesville, FL 32610 USA Univ Florida POB 100256 Gainesville FL USA 32610 le, FL 32610 USA
Citazione:
P. Blier, "Crosstalk between the norepinephrine and serotonin systems and its role inthe antidepressant response", J PSYCH NEU, 26, 2001, pp. S3-S10

Abstract

Many behavioural overlaps exist in the effects of norepinephrine (NE), serotonin (5-HT) and dopamine, and it is now thought that complex behaviour patterns may reflect interactions among these neurotransmitters, There is a wide variety of evidence for the pivotal role of the NE system in the pathogenesis and treatment of major depression. This paper discusses the functioning of the NE system, specifically the regulation of neuronal firing and the postsynaptic responses to NE, which can be controlled by norepinephrine reuptake inhibitors and other drugs. In addition, interactions between NE neurons and 5-HT neurons have implications for the treatment of depression and anxiety disorders. Specifically, the projections of 5-HT neurons have an inhibitory effect on NE neurons, which means that selective serotonin reuptake inhibitors also affect the NE system. Further experiments and long-termstudies will increase knowledge of the mechanisms of action of various psychopharmacologic agents and may eventually lead to better therapeutic choices.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:19:58