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Titolo:
Iontophoretic pulsatile transdermal delivery of human parathyroid hormone (1-34)
Autore:
Suzuki, Y; Iga, K; Yanai, S; Matsumoto, Y; Kawase, M; Fukuda, T; Adachi, H; Higo, N; Ogawa, Y;
Indirizzi:
Takeda Chem Ind Ltd, Div Pharmaceut Res,DDS Res Labs, Drugs Anal & Pharmacokinet & Drug Formulat, Yodogawa Ku, Osaka 5328686, Japan Takeda Chem Ind Ltd Osaka Japan 5328686 odogawa Ku, Osaka 5328686, Japan Takeda Chem Ind Ltd, Div Pharmaceut Res, Pharmaceut Res Labs, Yodogawa Ku,Osaka 5328686, Japan Takeda Chem Ind Ltd Osaka Japan 5328686 Yodogawa Ku,Osaka 5328686, Japan Hisamitsu Pharmaceut Co Inc, Tsukuba Res Labs, Tsukuba, Ibaraki 3050856, Japan Hisamitsu Pharmaceut Co Inc Tsukuba Ibaraki Japan 3050856 3050856, Japan
Titolo Testata:
JOURNAL OF PHARMACY AND PHARMACOLOGY
fascicolo: 9, volume: 53, anno: 2001,
pagine: 1227 - 1234
SICI:
0022-3573(200109)53:9<1227:IPTDOH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODELS; DRUG-DELIVERY; BONE MASS; INTERMITTENT; OSTEOPOROSIS; ELECTROOSMOSIS; ABSORPTION; MODULATION; MIGRATION; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, Y Takeda Chem Ind Ltd, Div Pharmaceut Res,DDS Res Labs, Drugs Anal& Pharmacokinet & Drug Formulat, Yodogawa Ku, 2-17-85 Jusohonmachi, Osaka 5328686, Japan Takeda Chem Ind Ltd 2-17-85 Jusohonmachi Osaka Japan 5328686 an
Citazione:
Y. Suzuki et al., "Iontophoretic pulsatile transdermal delivery of human parathyroid hormone (1-34)", J PHARM PHA, 53(9), 2001, pp. 1227-1234

Abstract

Iontophoretic pulsatile transdermal delivery of hPTH(1-34) was examined inSprague-Dawley (SD) rats, hairless rats and beagle dogs. Application for 60 min (200 mug; 0.1 mA cm(-2)) showed current-responsive increases in serumhPTH(1-34) levels in all the animals. In SID rats, the area under the curves of serum hPTH(1-34) levels (AUCs) were proportional to the doses (40, 120, 200, 400 and 1000 mug) and current densities (0.05, 0.1 and 0.15 mA cm(-2)) applied. The absorption rates per 200-mug dose, calculated by a deconvolution method, were 6.7, 2.4 and 3.7 mug h(-1) for SID rats, hairless rats and beagle dogs, respectively. These values correlated well with the ratiosof the skin porosity to the dermal thickness reported for these animals, which are believed to represent the reciprocal of the electrical resistance of the aqueous channels formed by the hair follicles. From this correlation, we suggested that absorption of hPTH(1-34) occurs mainly via the hair-follicle route, and that the absorption rate in man might be intermediate between those in hairless rats and beagle dogs. Three-fold repetitions of 30 min current with various rest intervals produced current-responsive triple pulses in serum hPTH(1-34) levels in SID rats. Seven-fold repetitions of current also produced similar current-responsive pulsatile serum hPTH(1-34) levels. However, peak serum hPTH(1-34) levels tended to decrease gradually after the fourth current application, possibly due to consumption of the electrodes, suggesting that three-fold repetitions of cur-rent might be optimal. These findings suggest that this iontophoretic administration system couldcreate a repeated-pulsatile pattern of serum hPTH(1-34) levels without thenecessity for frequent injections, and may be useful for the treatment of osteoporosis with hPTH(1-34).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:15:52