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Titolo:
Impaired esophageal reactivity in adriamycin-induced rat esophageal atresia: An in vitro study
Autore:
Tugay, M; Yildiz, F; Utkan, T; Ulak, G; Gacar, N; Erden, F;
Indirizzi:
Kochi Univ, Sch Med, Dept Pediat Surg & Pharmcol, Kocaeli, Turkey Kochi Univ Kocaeli Turkey Dept Pediat Surg & Pharmcol, Kocaeli, Turkey
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 10, volume: 36, anno: 2001,
pagine: 1569 - 1573
SICI:
0022-3468(200110)36:10<1569:IERIAR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACHEOESOPHAGEAL FISTULA; FETAL RATS; MALFORMATIONS; REPAIR; MODEL; DYSFUNCTION; RELAXATION; DISORDERS;
Keywords:
esophageal atresia; Adriamycin; carbachol; serotonin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tugay, M Kantarci Riza Sok Kismet Apt 6-4, TR-81080 Istanbul, Turkey Kantarci Riza Sok Kismet Apt 6-4 Istanbul Turkey TR-81080 urkey
Citazione:
M. Tugay et al., "Impaired esophageal reactivity in adriamycin-induced rat esophageal atresia: An in vitro study", J PED SURG, 36(10), 2001, pp. 1569-1573

Abstract

Purpose: The aim of this study was to investigate the reactivity of lower esophageal smooth muscle in the Adriamycin-induced esophageal atresia (EA) rat model. Methods: The fetuses were divided into 3 groups. The control group was exposed to saline. The second group comprised fetuses that were exposed to Adriamycin but in whom EA did not develop. The third group comprised of fetuses that were exposed to Adriamycin and EA was observed. The reactivity of distal esophageal strips was studied in organ chambers. Results: The tension was similar in all groups precontracted with carbachol for the study of relaxation to serotonin. Relaxation of lower esophageal strips to serotonin was comparably unaffected in the control and Adriamycin-no EA groups, whereas it was significantly inhibited in the EA group with decreased E-max and pD(2) values. Contractile responses of esophageal smooth muscle to carbachol or 80 mmol/L KCl and relaxant responses to papaverinewere similar in all groups. No change in agonist potency was observed among the groups. Conclusions: Our study showed impairment of serotonin-receptor-mediated relaxation; but not of cholinoceptor-mediated contraction of the lower esophageal smooth muscle in the EA. Thus, impaired relaxant responses may be, at least in part, a contributing factor in the esophageal dismotility seen in EA. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 01:08:26