Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Fractal analysis of cerebral blood flow distribution in Alzheimer's disease
Autore:
Nagao, M; Murase, K; Kikuchi, T; Ikeda, M; Nebu, A; Fukuhara, R; Sugawara, Y; Miki, H; Ikezoe, J;
Indirizzi:
Ehime Univ, Sch Med, Dept Radiol, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Osaka Univ, Sch Med, Dept Med Engn, Div Allied Hlth Sci, Suita, Osaka 565,Japan Osaka Univ Suita Osaka Japan 565 Allied Hlth Sci, Suita, Osaka 565,Japan
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 10, volume: 42, anno: 2001,
pagine: 1446 - 1450
SICI:
0161-5505(200110)42:10<1446:FAOCBF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; TECHNETIUM-99M-HMPAO SPECT; QUANTITATIVE-ANALYSIS; CHOLINERGIC NEURONS; SELECTIVE LOSS; DEMENTIA; HETEROGENEITY; BRAIN; DIAGNOSIS; EMPHYSEMA;
Keywords:
fractal analysis; cerebral blood flow; Alzheimer's disease; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nagao, M Ehime Univ, Sch Med, Dept Radiol, Shitsukawa, Shigenobu, Ehime 7910295, Japan Ehime Univ Shitsukawa Shigenobu Ehime Japan 7910295 910295, Japan
Citazione:
M. Nagao et al., "Fractal analysis of cerebral blood flow distribution in Alzheimer's disease", J NUCL MED, 42(10), 2001, pp. 1446-1450

Abstract

This study describes a method for quantifying cerebral blood flow (CBF) distribution in Alzheimer's disease (AD) from SPECT images obtained with Tc-99m-hexamethylpropyleneamine oxime (HMPAO) by 3-dimensional fractal analysis(3D-FA). Methods: HMPAO SPECT was performed on 68 patients with probable AD and 14 healthy control subjects. We delineated the CBF images using 4 cutoff levels (35%, 40%, 45%, and 50% of the maximal voxel radioactivity) and measured the total number of voxels in the areas surrounded by the contoursobtained with each cutoff level. We calculated fractal dimensions from therelationship between the total number of voxels and the cutoff levels transformed into natural logarithms. Results: The fractal dimensions (mean SD) for patients with probable AD and healthy subjects were 0.74 +/- 0.33 and 0.52 +/- 0.09, respectively. A significant difference in the fractal dimension was found between groups (P = 0.001). Statistically significant correlations were obtained between the fractal dimension and the Mini-Mental State Examination score (r = -0.598; P < 0.0001) and between the fractal dimension and the AD Assessment Scale (r = 0.670; P < 0.0001). The fractal dimensions for subjects with clinical dementia rates (CDRs) of 0, 1, 2, and 3 were 0.52 +/- 0.09, 0.63 +/- 0.21, 0.77 +/- 0.23 (P < 0.05 vs. the group with a CDR of 1), and 1.43 +/- 0.49 (P < 0.0001 vs. the group with a CDR of 2), respectively. Conclusion: Quantification of CBF distribution on SPECT images in AD was possible using 3D-FA. The fractal dimension was well correlated with the cognitive impairment, as assessed in neuropsychologic tests. 3D-FA may be a useful method for objectively evaluating the progression of AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:16:05