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Titolo:
Estimation of coronary flow reserve with the use of dynamic planar and SPECT images of Tc-99m tetrofosmin
Autore:
Sugihara, H; Yonekura, Y; Kataoka, K; Fukai, D; Kitamura, N; Taniguchi, Y;
Indirizzi:
Takashima Gen Hosp, Dept Internal Med, Shiga 5201123, Japan Takashima Gen Hosp Shiga Japan 5201123 nternal Med, Shiga 5201123, Japan Fukui Med Univ, Fukui, Japan Fukui Med Univ Fukui JapanFukui Med Univ, Fukui, Japan
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 575 - 579
SICI:
1071-3581(200109/10)8:5<575:EOCFRW>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW;
Keywords:
coronary flow reserve; single photon emission computed tomography; technetium 99m tetrofosmin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sugihara, H Takashima Gen Hosp, Dept Internal Med, 1667 Katsuno Takashimacho, Shiga 5201123, Japan Takashima Gen Hosp 1667 Katsuno Takashimacho Shiga Japan 5201123
Citazione:
H. Sugihara et al., "Estimation of coronary flow reserve with the use of dynamic planar and SPECT images of Tc-99m tetrofosmin", J NUCL CARD, 8(5), 2001, pp. 575-579

Abstract

Background. We developed a noninvasive method to examine coronary flow reserve with technetium 99m tetrofosmin based on the microsphere model. According to the microsphere model, myocardial blood flow (MBF) can be calculatedby MBF = q / integral C(t)dt, where q is myocardial activity and C(t) is tracer concentration in blood. Because the ratio of integral C(t)dt at stress to rest is equal to the ratio of the first transit count in the pulmonaryartery (PA) and attenuation factors were canceled out, we calculated the increase ratio of MBF (MBFIR). Methods and Results. After injection of dipyridamole, tetrofosmin was injected as a bolus and serial dynamic planar images were obtained to measure the first transit count in PA (PAC). Myocardial single photon emission computed tomography was performed to measure the regional myocardial count (RMC). MBFIR was calculated as [(RMCs x PACr)/(RMCr x PACs) -1] x 100, where r and s denote resting and stress conditions, respectively. In contrast, the increase in the myocardial uptake ratio (MURIR) was defined as (RMCs x SCr/RMCr x SCs - 1) x 100, where SC is syringe count of tracer. The results wereas follows: (1) The mean MBF of healthy subjects was 46.9%+/- 22.8%. (2) MBFIR of the infarcted region and ischemic region was significantly decreased (8.3%+/- 12.2% and 11.2%+/- 11.9%, respectively; P<.001). (3) MURIR was significantly lower than MBFIR (14.1%<plus/minus>21.2%; P<.001). (4) MBFIR decreased according to the heart rate at rest (r=0.47; P<.05). Conclusions. MBFIR is a potential parameter with which to evaluate coronary flow reserve when the changes of arterial input function during stress are considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:37:49