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Titolo:
Usefulness of distinct activity thresholds according to baseline regional asynergy for predicting functional recovery in patients with chronic coronary artery disease and left ventricular dysfunction: A study with nitrate-enhanced sestamibi gated SPECT
Autore:
Leoncini, M; Marcucci, G; Sciagra, R; Frascarelli, F; Bellandi, F; Gallopin, M; Mennuti, A; Dabizzi, RP;
Indirizzi:
Misericordia & Dolce Hosp, Div Cardiol, Prato, Italy Misericordia & Dolce Hosp Prato Italy e Hosp, Div Cardiol, Prato, Italy Misericordia & Dolce Hosp, Nucl Med Unit, Prato, Italy Misericordia & Dolce Hosp Prato Italy Hosp, Nucl Med Unit, Prato, Italy Univ Florence, Dept Clin Physiopathol, Nucl Med Unit, Florence, Italy UnivFlorence Florence Italy ysiopathol, Nucl Med Unit, Florence, Italy
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 555 - 560
SICI:
1071-3581(200109/10)8:5<555:UODATA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
REST-REDISTRIBUTION TL-201; TC-99M SESTAMIBI; MYOCARDIAL VIABILITY; DOBUTAMINE ECHOCARDIOGRAPHY; TOMOGRAPHY; REVASCULARIZATION; INFARCT; PERFUSION; SIZE;
Keywords:
coronary artery disease; gated single photon emission computed tomography; myocardial viability; sestamibi;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Leoncini, M Via Cittadino 24, I-59100 Prato, Italy Via Cittadino 24 Prato Italy I-59100 4, I-59100 Prato, Italy
Citazione:
M. Leoncini et al., "Usefulness of distinct activity thresholds according to baseline regional asynergy for predicting functional recovery in patients with chronic coronary artery disease and left ventricular dysfunction: A study with nitrate-enhanced sestamibi gated SPECT", J NUCL CARD, 8(5), 2001, pp. 555-560

Abstract

Background. The role of gated single photon emission computed tomography (SPECT) in improving viability detection with the use of perfusion imaging is uncertain. This study aimed to verify whether the classification of baseline regional dysfunction with gated SPECT helps to predict functional recovery with the use of quantitative perfusion imaging. Methods and Results. Resting nitrate-enhanced sestamibi gated SPECT was performed in 31 patients with left ventricular dysfunction, who later underwent coronary revascularization. With the use of a 16-segment model, tracer activity was quantified, and wall motion and thickening were estimated with a 4-point scoring scheme. Reversible dysfunction was assessed with followupgated SPECT. According to receiver operating characteristic curve analysis, the best overall cutoff for predicting reversible dysfunction in asynergic segments was 50% of peak activity or greater, with 83% sensitivity, 54% specificity, and 64% accuracy. When the segments were divided according to wall motion in resting gated SPECT, the optimal activity cutoff was greater than 68% for hypokinetic and 50% or greater for adyskinetic segments. With the use of 2 thresholds, the overall sensitivity remained good (76%), whereas specificity increased to 73% (P<.0005) and accuracy to 74% (P<.02). Conclusions. Regional dysfunction assessment directly on perfusion images permits use of different activity thresholds with an improvement over a single cutoff for all asynergic segments. Therefore combining perfusion and functional data with nitrate-enhanced gated SPECT at rest appears to be a promising approach for viability detection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:52:16