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Titolo:
RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS
Autore:
Sakakibara, S; Nakamura, Y; Satoh, H; Okano, H;
Indirizzi:
Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Physiol, Shinjuku Ku, Tokyo 1608582, Japan Osaka Univ, Grad Sch Med, Biomed Res Ctr, Dept Neurosci,Div Neuroanat, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 uroanat, Suita, Osaka 5650871, Japan Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan Japan Sci & Technol Corp Kawaguchi Saitama Japan 3320012 a 3320012, Japan Univ Tokyo, Inst Med Sci, Dept Canc Res, Div Pathol,Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 iv Pathol,Minato Ku, Tokyo 1088639, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 20, volume: 21, anno: 2001,
pagine: 8091 - 8107
SICI:
0270-6474(20011015)21:20<8091:RPMDRE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; STEM-CELLS; SUBVENTRICULAR ZONE; PROGENITOR CELLS; CEREBRAL-CORTEX; RAT HIPPOCAMPUS; SUBEPENDYMAL CELLS; GENE-EXPRESSION; PARVALBUMIN; FOREBRAIN;
Keywords:
RNA-binding protein; Musashi2; Musashi1; CNS; development; neural precursor cells; CNS stem cell; astrocyte; parvalbumin; GABAergic neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Okano, H Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 kyo 1608582, Japan
Citazione:
S. Sakakibara et al., "RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS", J NEUROSC, 21(20), 2001, pp. 8091-8107

Abstract

Musashi1 (Msi1) is a mammalian neural RNA-binding protein highly enriched in neural precursor cells that are capable of generating both neurons and glia during embryonic and postnatal CNS development. Here, we identified Musashi2 (Msi2), a novel mammalian RNA-binding protein that exhibits high sequence similarity to Msi1. The Msi2 transcript appeared to be distributed ubiquitously in a wide variety of tissues, consistent with the mRNA distribution of its Xenopus homolog, xrp1. However, the present study revealed cell type-specific and developmentally regulated expression of Msi2 in the mammalian CNS. Interestingly, Msi2 was expressed prominently in precursor cells in the ventricular zone and subventricular zone with the same pattern as Msi1 throughout CNS development. In the postnatal and adult CNS, this concurrent expression of Msi2 and Msi1 was seen in cells of the astrocyte lineage, including ependymal cells, a possible source for postnatal CNS stem cells. During neurogenesis, the expression of both Msi2 and Msi1 was lost in most postmitotic neurons, whereas Msi2 expression persisted in a subset of neuronal lineage cells, such as parvalbumin-containing GABA neurons in the neocortex and neurons in several nuclei of the basal ganglia. Msi2 may have a unique role that is required for the generation and/or maintenance of specific neuronal lineages. Furthermore, in vitro studies showed that Msi2 and Msi1 have similar RNA-binding specificity. These two RNA-binding proteins may exert common functions in neural precursor cells by regulating gene expression at the post-transcriptional level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:00:13