Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Induction of mossy fiber -> CA3 long-term potentiation requires translocation of synaptically released Zn2+
Autore:
Li, Y; Hough, CJ; Frederickson, CJ; Sarvey, JM;
Indirizzi:
Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20814 Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20814 Bethesda, MD 20814 USA Univ Texas, Med Branch, Dept Biomed Engn, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 pt Biomed Engn, Galveston, TX 77550 USA Univ Texas, Med Branch, Dept Anat, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 nch, Dept Anat, Galveston, TX 77550 USA Univ Texas, Med Branch, Dept Neurosci, Galveston, TX 77550 USA Univ TexasGalveston TX USA 77550 Dept Neurosci, Galveston, TX 77550 USA NeuroBio Tex Inc, Galveston, TX 77550 USA NeuroBio Tex Inc Galveston TX USA 77550 Tex Inc, Galveston, TX 77550 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 20, volume: 21, anno: 2001,
pagine: 8015 - 8025
SICI:
0270-6474(20011015)21:20<8015:IOMF-C>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; PROTEIN-KINASE-II; HIPPOCAMPAL-NEURONS; KAINATE RECEPTORS; ZINC INHIBITION; SYNAPSES; PHOSPHORYLATION; TRANSMISSION; ACTIVATION; LTP;
Keywords:
zinc; long-term potentiation; CA3; hippocampus; CaEDTA; mossy fiber; plasticity; Na-pyrithione; Newport Green; synaptic transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Sarvey, JM Uniformed Serv Univ Hlth Sci, Dept Pharmacol, 4301 Jones BridgeRd, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci 4301 Jones Bridge Rd Bethesda MD USA 20814
Citazione:
Y. Li et al., "Induction of mossy fiber -> CA3 long-term potentiation requires translocation of synaptically released Zn2+", J NEUROSC, 21(20), 2001, pp. 8015-8025

Abstract

The mammalian CNS contains an abundance of chelatable Zn2+ sequestered in the vesicles of glutamatergic terminals. These vesicles are particularly numerous in hippocampal mossy fiber synapses of the hilar and CA3 regions. Our recent observation of frequency-dependent Zn2+ release from mossy fiber synaptic terminals and subsequent entry into postsynaptic neurons has prompted us to investigate the role of synaptically released Zn2+ in the induction of long-term potentiation (LTP) in field CA3 of the hippocampus. The rapid removal of synaptically released Zn2+ with the membrane-impermeable Zn2+ chelator CaEDTA (10 mM) blocked induction of NMDA receptor-independent mossy fiber LTP by high-frequency electrical stimulation (HFS) in rat hippocampal slices. Mimicking Zn2+ release by bath application of Zn2+ (50-100 muM) without HFS induced a long-lasting potentiation of synaptic transmission that lasted more than 3 hr. Moreover, our experiments indicate the effects ofZn2+ were not attributable to its interaction with extracellular membrane proteins but required its entry into presynaptic or postsynaptic neurons. Co-released glutamate is also essential for induction of LTP under physiological conditions, in part because it allows Zn2+ entry into postsynaptic neurons. These results indicate that synaptically released Zn2+, acting as a second messenger, is necessary for the induction of LTP at mossy fiber-->CA3synapses of hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 09:55:04