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Titolo:
An evaluation of synapse independence
Autore:
Barbour, B;
Indirizzi:
Ecole Normale Super, Neurobiol Lab, CNRS, Unite Mixte Rech 8544, F-75230 Paris 05, France Ecole Normale Super Paris France 05 Rech 8544, F-75230 Paris 05, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 20, volume: 21, anno: 2001,
pagine: 7969 - 7984
SICI:
0270-6474(20011015)21:20<7969:AEOSI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTICALLY RELEASED GLUTAMATE; AMPA RECEPTOR DESENSITIZATION; BERGMANN GLIAL-CELLS; HIPPOCAMPAL SYNAPSES; EXTRACELLULAR-SPACE; TIME-COURSE; EXTRASYNAPTIC GLUTAMATE; SILENT SYNAPSES; RAT HIPPOCAMPUS; NMDA RECEPTORS;
Keywords:
glutamate; synapse; AMPA; NMDA; transporter; synaptic transmission; diffusion; tortuosity; volume fraction; porous medium; synaptic cleft; vesicle; neurotransmitter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Barbour, B Ecole Normale Super, Neurobiol Lab, CNRS, Unite Mixte Rech 8544, 46 Rue Ulm, F-75230 Paris 05, France Ecole Normale Super 46 Rue Ulm Paris France 05 aris 05, France
Citazione:
B. Barbour, "An evaluation of synapse independence", J NEUROSC, 21(20), 2001, pp. 7969-7984

Abstract

If, as is widely believed, information is stored in the brain as distributed modifications of synaptic efficacy, it can be argued that the storage capacity of the brain will be maximized if the number of synapses that operate independently is as large as possible. The majority of synapses in the brain are glutamatergic; their independence will be compromised if glutamate released at one synapse can significantly activate receptors at neighboringsynapses. There is currently no agreement on whether "spillover" after theliberation of a vesicle will significantly activate receptors at neighboring synapses. To evaluate the independence of central synapses, it is necessary to compare synaptic responses with those generated at neighboring synapses by glutamate spillover. Here, synaptic activation and spillover responses are simulated in a model, based on data for hippocampal synapses, that includes an approximate representation of the extrasynaptic space. Recently-published data on glutamate transporter distribution and properties are incorporated. Factors likely to influence synaptic or spillover responses are investigated. For release of one vesicle, it is estimated that the mean response at the nearest neighboring synapse will be <5% of the synaptic response. It is concluded that synapses can operate independently.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:04:21