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Titolo:
The role of leptin in the regulation of energy balance and adiposity
Autore:
van Dijk, G;
Indirizzi:
Univ Groningen, Sch Behav & Cognit Neurosci, Div Neuroendocrinol, Dept Anim Physiol, NL-9750 AA Haren, Netherlands Univ Groningen Haren NetherlandsNL-9750 AA L-9750 AA Haren, Netherlands
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 10, volume: 13, anno: 2001,
pagine: 913 - 921
SICI:
0953-8194(200110)13:10<913:TROLIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; OBESE GENE-PRODUCT; NEUROPEPTIDE-Y; FOOD-INTAKE; ZUCKER RATS; PARAVENTRICULAR NUCLEUS; MELANOCORTIN SYSTEM; ARCUATE NUCLEUS; BODY-WEIGHT; RECEPTOR;
Keywords:
food intake; body weight; hypothalamus; neuropeptide; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: van Dijk, G Univ Groningen, Sch Behav & Cognit Neurosci, Div Neuroendocrinol, Dept Anim Physiol, POB 14, NL-9750 AA Haren, Netherlands Univ GroningenPOB 14 Haren Netherlands NL-9750 AA etherlands
Citazione:
G. van Dijk, "The role of leptin in the regulation of energy balance and adiposity", J NEUROENDO, 13(10), 2001, pp. 913-921

Abstract

Since its discovery, leptin (a 167-amino acid product of the OB gene) has quickly moved to the forefront as an important hormone for regulation of energy balance. It closes a feedback loop from adipose tissue to hypothalamicneuropeptide-containing neural circuitry involved in regulation of food intake and neuroendocrine/autonomic outflow. While increased central leptin signalling reduces adiposity via a reduction in food intake, it also has remarkable metabolic effects that promote leanness, independent of food intake. These include: (i) increased energy expenditure, (ii) in-place degradation of fat, and (iii) increased thermogenesis. Hypothalamic neurones that synthesize corticotropin releasing hormone and melanocortins (i.e. alpha -melanocyte-stimulating hormone and agouti-related protein) are likely effector pathways that mediate the anorexigenic and metabolic effects of leptin. Activation of sympathetic outflow (via neuropeptidergic effector pathways of central leptin) to a number of tissues that store fat might be an important mechanism through which these peripheral metabolic effects are elicited. Itis proposed that these peripheral metabolic effects contribute to the satiating properties of leptin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:00:28