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Titolo:
Chronic antidepressant treatments decrease pro-opiomelanocortin mRNA expression in the pituitary gland: Effects of acute stress and 5-HT1A receptor activation
Autore:
Jensen, JB; Mork, A; Mikkelsen, JD;
Indirizzi:
H Lundbeck & Co AS, Dept Neurobiol, Copenhagen, Denmark H Lundbeck & Co AS Copenhagen Denmark pt Neurobiol, Copenhagen, Denmark H Lundbeck & Co AS, Dept Neurochem & Discovery ADME, Copenhagen, Denmark HLundbeck & Co AS Copenhagen Denmark scovery ADME, Copenhagen, Denmark Bispebjerg Hosp, Dept Clin Biochem, DK-2400 Copenhagen, Denmark BispebjergHosp Copenhagen Denmark DK-2400 , DK-2400 Copenhagen, Denmark
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 10, volume: 13, anno: 2001,
pagine: 887 - 893
SICI:
0953-8194(200110)13:10<887:CATDPM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; LONG-TERM TREATMENT; GENE-EXPRESSION; MESSENGER-RNA; RAT-BRAIN; NEUROENDOCRINE RESPONSES; ADRENOCORTICAL REGULATION; DEPRESSED-PATIENTS; MAJOR DEPRESSION; G(O) PROTEINS;
Keywords:
POMC; antidepressants; pituitary; citalopram; SSRI; ECS; stress; 5-HT1A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Jensen, JB Azign Biosci AS, Vestre Teglgade 10, DK-2450 Copenhagen SV, Denmark Azign Biosci AS Vestre Teglgade 10 Copenhagen Denmark SV nmark
Citazione:
J.B. Jensen et al., "Chronic antidepressant treatments decrease pro-opiomelanocortin mRNA expression in the pituitary gland: Effects of acute stress and 5-HT1A receptor activation", J NEUROENDO, 13(10), 2001, pp. 887-893

Abstract

Consistent findings in depressed patients are hyperactivity in the hypothalamic-pituitary-adrenal (HPA) axis with high plasma concentrations of adrenocorticotropic hormone and cortisol. Long-term antidepressant treatments seem to normalize this hyperactivity, suggesting a link between the HPA axis and the action of antidepressant treatments. The present study was carried out to study the effects of antidepressant treatments on pro-opiomelanocortin (POMC) mRNA expression, with a focus on interaction with acute stress and 5-HT1A receptor activation. Male rats were treated for 21 days with saline, citalopram, fluoxetine, moclobemide or desipramine, and the expression of POMC mRNA in the anterior pituitary was analysed by semi-quantitative in situ hybridization. All antidepressants, but not saline, cocaine and haloperidol, reduced POMC mRNA expression. The decrease in POMC mRNA was not observed until 9 days of citalopram treatment. Decreased POMC mRNA levels were also observed after 14 days of repeated electroconvulsive stimulation, The decreased POMC mRNA levels did not affect the stress-induced POMC mRNA increase, measured following swim stress and restraint stress. Finally, using Fos as a marker for neural activity, we showed attenuation of 8-OH-DPAT-stimulated activity in the paraventricular nucleus following 21 days of citalopram treatment. In conclusion, antidepressant treatments decrease basal POMCmRNA expression without affecting the acute stress response, and the reduced POMC mRNA may be related to reduced 5-HT1A-stimulated hypothalamic output.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:50:53