Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta
Autore:
Wick, W; Platten, M; Weller, M;
Indirizzi:
Univ Tubingen, Sch Med, Dept Neurol, Mol Neurooncol Lab, D-72076 Tubingen,Germany Univ Tubingen Tubingen Germany D-72076 col Lab, D-72076 Tubingen,Germany
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 2, volume: 53, anno: 2001,
pagine: 177 - 185
SICI:
0167-594X(2001)53:2<177:GCIROM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; HUMAN GLIOBLASTOMA; IN-VITRO; INTEGRIN EXPRESSION; MALIGNANT GLIOMA; UP-REGULATION; TUMOR-CELLS; ACTIVATION; MATRIX;
Keywords:
transforming growth factor-beta; hepatocyte growth factor; brain tumor; BCL-xL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Wick, W Univ Tubingen, Sch Med, Dept Neurol, Mol Neurooncol Lab, Hoppe Seyler Str 3, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 3 Tubingen Germany D-72076 Germany
Citazione:
W. Wick et al., "Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta", J NEURO-ONC, 53(2), 2001, pp. 177-185

Abstract

Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases that selectively degrade components of the extracellular matrix. MMPs are implicated in tumor cell invasion because they mediate the breakdown of the basal membrane. In addition, they seem to be important for the creationand maintenance of a microenvironment that facilitates tumor cell survival. Among the essential characteristics of human malignant gliomas are infiltrative growth, angiogenesis and suppression of antitumor immune surveillance. Transforming growth factor-beta (TGF-beta) is intimately involved in theregulation of these processes. We have previously demonstrated that TGF-beta promotes the migration of LN-18 and LN-229 glioma cells via a process that may involve the upregulation of alpha (V)beta (3) integrin expression. Furthermore, we have defined a novel pathway for hepatocyte growth factor (HGF)-induced glioma cell migration and invasion which requires the inductionof TGF-beta (2) expression. Here, we demonstrate that TGF-beta (2) inducesMMP-2 expression and suppresses tissue inhibitor of metalloproteinases (TIMP)-2 expression and that concentration-dependently promotes the invasion of U87MG and LN-229 glioma cells in a matrigel invasion assay. Similarly, ectopic expression of the anti-apoptotic BCL-x(L) protein leads to enhanced matrigel invasion by LN-18 and LN-229 glioma cells. We outline the possible interrelations of TGF-beta, proteins of the BCL-2 family, integrins and metalloprotease activity. By virtue of its promotion of glioma invasion and its growth regulatory and immunomodulatory properties, TGF-beta continues to be one of the most promising targets for the experimental therapy of human malignant glioma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:07:50