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Titolo:
Identification of a novel truncated isoform of trkB in the kitten primary visual cortex
Autore:
Forooghian, F; Kojic, L; Gu, Q; Prasad, SS;
Indirizzi:
Univ British Columbia, Dept Ophthalmol, Vancouver, BC V5Z 3N9, Canada UnivBritish Columbia Vancouver BC Canada V5Z 3N9 ver, BC V5Z 3N9, Canada Univ British Columbia, Brain Res Ctr, Vancouver, BC V5Z 3N9, Canada Univ British Columbia Vancouver BC Canada V5Z 3N9 ver, BC V5Z 3N9, Canada
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 1, volume: 17, anno: 2001,
pagine: 81 - 88
SICI:
0895-8696(200108)17:1<81:IOANTI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROTROPHIC FACTOR; TYROSINE KINASE; RECEPTOR; BRAIN; CLONING; BDNF; PLASTICITY; SEQUENCE; GROWTH; INTERNALIZATION;
Keywords:
neurotrophins; trkB; truncated receptor; RT-PCR; DNA sequence analysis; kitten; visual cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Prasad, SS Univ British Columbia, Dept Ophthalmol, Vancouver, BC V5Z 3N9, Canada Univ British Columbia Vancouver BC Canada V5Z 3N9 3N9, Canada
Citazione:
F. Forooghian et al., "Identification of a novel truncated isoform of trkB in the kitten primary visual cortex", J MOL NEURO, 17(1), 2001, pp. 81-88

Abstract

Neurotrophins have been shown to play important roles in development and plasticity of the visual cortex (VC). Since signal transduction of neurotrophins is mediated through neurotrophin receptors, we attempted to analyze neurotrophin receptors in the VC. In this study, we isolated cDNAs encoding the intracellular regions of truncated isoforms of the trkB receptor from 30-d-old kitten primary VC. Two distinct truncated isoforms of trkB were isolated and characterized by sequence analyses. One of the isoforms corresponds to the previously described truncated trkB in several mammalian species. The second isoform. represents a novel truncated trkB variant form in the kitten VC. Sequence analysis revealed that this contains a sequence that hasnot yet been reported in any species. This novel isoform, designated trkB.T4, results from alternative splicing 189-bp (63 amino acids) downstream from the splice site giving rise to the first known truncated isoforms of trkB. In the context of recent hypotheses regarding the function of truncated trkB receptors, sequence analysis indicates that trkB.T4 may bear putative signaling/internalization sequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:09:36