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Titolo:
Performance of the analytical assays of paclitaxel, docetaxel, and cyclosporin a in a routine hospital laboratory setting
Autore:
Malingre, MM; Rosing, H; Koopman, FJ; Schellens, JHM; Beijnen, JH;
Indirizzi:
Slotervaart Hosp, Netherlands Canc Inst, Dept Pharm & Pharmacol, NL-1066 EC Amsterdam, Netherlands Slotervaart Hosp Amsterdam Netherlands NL-1066 EC Amsterdam, Netherlands Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Med Oncol, NL-1066 CX Amsterdam, Netherlands Antoni van Leeuwenhoek Hosp Amsterdam Netherlands NL-1066 CX Netherlands Univ Utrecht, Fac Pharm, Div Drug Toxicol, NL-3584 CA Utrecht, NetherlandsUniv Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 17, volume: 24, anno: 2001,
pagine: 2697 - 2717
SICI:
1082-6076(2001)24:17<2697:POTAAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHIC METHOD; ADVANCED OVARIAN-CANCER; SOLID-PHASE EXTRACTION; ENABLES ORAL-THERAPY; HUMAN-PLASMA; POLARIZATION IMMUNOASSAY; BIOLOGICAL-ACTIVITY; HUMAN FECES; PHARMACOKINETICS; METABOLITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Malingre, MM Slotervaart Hosp, Netherlands Canc Inst, Dept Pharm & Pharmacol, Louwesweg6, NL-1066 EC Amsterdam, Netherlands Slotervaart Hosp Louwesweg 6 Amsterdam Netherlands NL-1066 EC
Citazione:
M.M. Malingre et al., "Performance of the analytical assays of paclitaxel, docetaxel, and cyclosporin a in a routine hospital laboratory setting", J LIQ CHR R, 24(17), 2001, pp. 2697-2717

Abstract

The taxanes paclitaxel and docetaxel are important anticancer agents. To optimize therapy of these drugs, many studies have been performed by us withpharmacokinetic monitoring of the compounds. The numerous determinations of paclitaxel and docetaxel in our laboratory enabled us to monitor performance of the bioanalytical assays over a prolonged period of time. In addition, we analyzed the performance of the bioanalytical assay of cyclosporin A,a compound co-administered to enhance absorption of orally administered paclitaxel and docetaxel. Here, we report our experience with these assays over the past four years. Paclitaxel and docetaxel were analyzed by validated high-performance liquid chromatography (HPLC) assays developed at our Institute. Cyclosporin A was analyzed with use of a specific fluorescence polarization immunoassay (s-FPIA) developed and validated by Abbott Laboratories. For acceptance of an analytical run, we used the criteria for calibration and quality control samples issued by the conference on Analytical Methods Validation (1990). Quality control samples have been used to monitor performance of the assays. In the past four years, all three analytical assays showed excellent performance. In this period, we performed 84 analytical runs of paclitaxel, 19 runs of docetaxel, and 131 runs of cyclosporin A. Accuracies of the paclitaxel, docetaxel, and cyclosporin A assays were 92-102%, 103-112%, and 103-105%, respectively. Precisions of the paclitaxel and docetaxel assays were less than 10% for all concentrations. For the cyclosporin A assay, the coefficients of variation were always less than 12%. It can be concluded that the validated analytical assays of paclitaxel, docetaxel, and cyclosporin A showed very good performance in a routine hospital laboratory setting for a prolonged period of time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:07:36