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Titolo:
Constitutive and interleukin-7-and interleukin-15-stimulated DNA binding of STAT and novel factors in cutaneous T cell lymphoma cells
Autore:
Qin, JZ; Kamarashev, J; Zhang, CL; Dummer, R; Burg, G; Dobbeling, U;
Indirizzi:
Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 3, volume: 117, anno: 2001,
pagine: 583 - 589
SICI:
0022-202X(200109)117:3<583:CAIIDB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRAVIOLET-B RADIATION; RECEPTOR-BETA-CHAIN; SEZARY-SYNDROME; IL-2 RECEPTOR; GROWTH-FACTOR; TYROSINE PHOSPHORYLATION; TRANSCRIPTION FACTORS; SIGNAL-TRANSDUCTION; MYCOSIS-FUNGOIDES; JAK/STAT PROTEINS;
Keywords:
gene regulation; oncogenes; signal transduction; transcription factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Dobbeling, U Univ Zurich Hosp, Dept Dermatol, Gloriastr 31, CH-8091 Zurich, Switzerland Univ Zurich Hosp Gloriastr 31 Zurich Switzerland CH-8091 and
Citazione:
J.Z. Qin et al., "Constitutive and interleukin-7-and interleukin-15-stimulated DNA binding of STAT and novel factors in cutaneous T cell lymphoma cells", J INVES DER, 117(3), 2001, pp. 583-589

Abstract

On testing cutaneous T cell lymphoma cell lines and skin lesions, we foundthat the transcription factors STAT2, STAT3, STAT5, and STAT6 (STAT, signal transducer and activator of transcription) were present in the nuclei of these cells and that the binding to their specific DNA binding sites was stimulated by interleukin-7 and interleukin-15. DNA binding studies also revealed the presence of three additional DNA factors in cutaneous T cell lymphoma cells that bound to the same sequences and could also be stimulated by interleukin-7 and interleukin-15. One of these novel factors was also present in the adult T cell leukemia cell line jurkat and malignant T cells fromthe blood of Sezary syndrome patients, but not in normal peripheral blood lymphocytes. It may therefore be a marker of T cell leukemia. It seems to interfere with the binding of STAT1 to the sis inducible element, suggestingthat the DNA binding activity of STAT1 in cutaneous T cell lymphoma cells is disturbed.

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Documento generato il 09/04/20 alle ore 07:31:00