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Titolo:
Ventricular production of natriuretic peptides and ventricular structural remodeling in hypertensive heart failure
Autore:
Sakata, Y; Yamamoto, K; Masuyama, T; Mano, T; Nishikawa, N; Kuzuya, T; Miwa, T; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 peut A8, Suita, Osaka 5650871, Japan Osaka Univ, Genome Informat Res Ctr, Suita, Osaka, Japan Osaka Univ SuitaOsaka Japan enome Informat Res Ctr, Suita, Osaka, Japan
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 10, volume: 19, anno: 2001,
pagine: 1905 - 1912
SICI:
0263-6352(200110)19:10<1905:VPONPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITION; CARDIAC HORMONE; MESSENGER-RNA; HYPERTROPHY; DYSFUNCTION; SYSTEM; RATS; ENDOTHELIN-1; EXPRESSION; TRANSITION;
Keywords:
angiotensin; fibrosis; heart failure; hypertension; natriuretic peptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, K Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, 2-2 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
Y. Sakata et al., "Ventricular production of natriuretic peptides and ventricular structural remodeling in hypertensive heart failure", J HYPERTENS, 19(10), 2001, pp. 1905-1912

Abstract

Objectives Brain natriuretic peptide (BNP) is a strong predictor of left ventricular (LV) hypertrophy (LVH) and dysfunction. However, our recent studies suggested that LVH is not necessarily associated with enhanced production of BNP in hypertension. This study aimed to clarify the relation of the characteristics of hypertrophy with the degree of gene expression of BNP inthe developmental process of hypertensive heart failure. Methods Serial changes in LV geometry, histology and atrial natriuretic peptide (ANP) and BNP mRNA levels, were assessed in a hypertensive heart failure model using Dahl salt-sensitive rats (n = 24). We further studied effects of alpha (1)-receptor antagonist (doxazosin: 1 mg/kg per day, n = 5) andangiotensin 11 type I receptor (AT, R) antagonist (candesartan cilexetil: I mg/kg per day, n = 5). Results The BNP mRNA level was not elevated at the compensatory hypertrophic stage when ANP mRNA level was elevated. BNP mRNA level was increased with further progression of hypertrophy and development of fibrosis. AT, R blockade prevented such fibrosis and further progression of hypertrophy with normalization of BNP mRNA levels. Compensatory hypertrophy was not suppressed; therefore, ANP mRNA level, although decreased, was still beyond the normal level. The alpha (1)-receptor blockade slightly attenuated LV hypertrophy with a slight decrease in ANP mRNA levels. LV fibrosis was not prevented,and the BNP mRNA level was not decreased. Conclusions BNP gene expression is not enhanced by initial compensatory hypertrophy, but is enhanced by LV fibrosis and late stage progression of hypertrophy dependent on AT, R-mediated signaling pathway. (C) 2001 LippincottWilliams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:56:29