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Titolo:
Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure
Autore:
Kohzuki, M; Kamimoto, M; Wu, XM; Xu, HL; Kawamura, T; Mori, N; Nagasaka, M; Kurosawa, H; Minami, N; Kanazawa, M; Saito, T; Yoshida, K;
Indirizzi:
Tohoku Univ, Grad Sch Med, Dept Internal Med & Rehabil Sci, Sendai, Miyagi9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Sci, Sendai, Miyagi9808574, Japan Fukuoka Univ, Sch Med, Dept Internal Med 4, Fukuoka 81401, Japan Fukuoka Univ Fukuoka Japan 81401 pt Internal Med 4, Fukuoka 81401, Japan
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 10, volume: 19, anno: 2001,
pagine: 1877 - 1882
SICI:
0263-6352(200110)19:10<1877:RPEOCE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITORS; STREPTOZOTOCIN-DIABETIC RATS; ANGIOTENSIN-II; HEMODIALYSIS-PATIENTS; DISEASE; PROGRESSION;
Keywords:
exercise; proteinuria; kidney; blood pressure; spontaneously hypertensive rats; renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kohzuki, M Tohoku Univ, Grad Sch Med, Dept Internal Med & Rehabil Sci, Sendai, Miyagi9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 , Miyagi9808574, Japan
Citazione:
M. Kohzuki et al., "Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure", J HYPERTENS, 19(10), 2001, pp. 1877-1882

Abstract

Objectives Patients with chronic renal failure are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of renal disease. Similarly, there are few animal models concerned with the effect of exercise training on improving renal function. Therefore, we assessed the renal effects of moderate chronic treadmill exercise in a remnant kidney model of spontaneously hypertensive rats (SHR) with chronic renal failure. We also assessed the effects of exercise and antihypertensive therapy on renal function. Design and methods Eight-week-old SHR were subjected to 5/6 nephrectomy byremoval of the left kidney and excision of two-thirds of the right kidney. The rats were divided into four groups: (i) no exercise (Non-EX); (ii) moderate exercise with treadmill running (20 m/min, 0 grade incline for 60 min) (EX); (iii) EX with an angiotensin converting enzyme (ACE) inhibitor, enalapril (2 mg/kg per day, i.p.); and (iv) EX with an angiotensin receptor antagonist, losartan (5 mg/kg per day, i.p.), for 4 weeks. Results Chronic EX significantly attenuated the increase in proteinuria (P< 0.01) and significantly protected against increases in the index of glomerular sclerosis OGS). Both enalapril and losartan with EX significantly decreased blood pressure (P < 0.001), and further decreased the IGS. In the stepwise multiple regression analysis, only antihypertensive drug remained in the model as a significant predictor of IGS (P < 0.0001). In contrast, exercise, antihypertensive drug and mean systolic blood pressure (weeks 1-4) remained in the model as a significant predictors of mean proteinuria (weeks 1-4) (all P < 0.0001). Conclusions These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of rats. Moreover, the antihypertensive therapy has additional renal-protective effects in this model of rats. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:28:05