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Titolo:
Gene therapy for cystic fibrosis
Autore:
Davies, JC; Geddes, DM; Alton, EWFW;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Gene Therapy, London SW3 6LR, England Univ London Imperial Coll Sci Technol& Med London England SW3 6LR gland
Titolo Testata:
JOURNAL OF GENE MEDICINE
fascicolo: 5, volume: 3, anno: 2001,
pagine: 409 - 417
SICI:
1099-498X(200109/10)3:5<409:GTFCF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMEMBRANE CONDUCTANCE REGULATOR; AIRWAY EPITHELIAL-CELLS; NASAL EPITHELIUM; PSEUDOMONAS-AERUGINOSA; CHLORIDE CHANNEL; PHASE-I; RECOMBINANT ADENOVIRUS; ADENOASSOCIATED VIRUS; SUBMUCOSAL GLANDS; RESPIRATORY-TRACT;
Keywords:
cystic fibrosis; gene therapy; CFTR; adenovirus; cationic liposome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, JC Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Gene Therapy, Manresa Rd, London SW3 6LR, England Univ London Imperial Coll Sci Technol & Med Manresa Rd London England SW3 6LR
Citazione:
J.C. Davies et al., "Gene therapy for cystic fibrosis", J GENE MED, 3(5), 2001, pp. 409-417

Abstract

Cystic fibrosis (CF) is associated with significant morbidity and mortality, despite significant advances in conventional treatment. The field of gene therapy has progressed rapidly since the cystic fibrosis transmembrane conductance regulator (CFTR) gene was cloned. In this review we discuss current knowledge on the underlying molecular defect in CF, and the progress in gene transfer studies from the early in vitro work through to clinical trials, including the development of endpoints to assess efficacy. We highlightthe problems encountered, and likely future directions of the field. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:39:56