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Titolo:
The Sardinian Autoimmunity Study. 4. Thyroid and islet cell autoantibodiesin Sardinian pregnant women at delivery: A cross-sectional study
Autore:
Olivieri, A; Pinna, G; Lai, A; Velluzzi, F; Pilo, A; Atzeni, F; Guaita, G; Pelligra, I; Cirillo, R; Sorcini, M; Carta, S; Bottazzo, GF; Mariotti, S;
Indirizzi:
Univ Cagliari, Dept Med Sci M Aresu, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 ci M Aresu, I-09124 Cagliari, Italy Osped Bambino Gesu, Inst Sci, IRCCS, Rome, Italy Osped Bambino Gesu RomeItaly ambino Gesu, Inst Sci, IRCCS, Rome, Italy Ist Super Sanita, Lab Metab & Pathol Biochem, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 Pathol Biochem, I-00161 Rome, Italy
Titolo Testata:
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
fascicolo: 8, volume: 24, anno: 2001,
pagine: 570 - 574
SICI:
0391-4097(200109)24:8<570:TSAS4T>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; POSTPARTUM THYROIDITIS; CELIAC-DISEASE; ANTIBODIES; DYSFUNCTION; POPULATION; EPIDEMIOLOGY; PREDICTION; IDDM;
Keywords:
post-partum thyroiditis; diabetes mellitus; pregnancy; thyroid antibodies; islet cell antibodies; thyroid autoimmunity; Type 1 diabetes mellitus; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Mariotti, S Univ Cagliari, Dept Med Sci M Aresu, Via S Giorgio 12, I-09124Cagliari, Italy Univ Cagliari Via S Giorgio 12 Cagliari Italy I-09124 , Italy
Citazione:
A. Olivieri et al., "The Sardinian Autoimmunity Study. 4. Thyroid and islet cell autoantibodiesin Sardinian pregnant women at delivery: A cross-sectional study", J ENDOC INV, 24(8), 2001, pp. 570-574

Abstract

A high incidence of autoimmune Type 1 diabetes mellitus (DM) has been clearly established in Sardinia. Although systematic epidemiological studies are still not available, an increased prevalence of thyroid autoantibodies (ATA) has been documented in the Sardinian adult population as compared to other Italian regions, suggesting that thyroid autoimmune disease may also have increased. We carried out a preliminary study with the aim of determining the prevalence of serological markers of thyroid (anti-thyroperoxydase antibodies, TPOAb) and islet cell (ICA) autoimmunity in a large number (no.=2249) of sera obtained from cord-blood of Sardinian pregnant women at delivery. The prevalence of TPOAb was 11.9%, while ICA were detected in 59 cases (2.6%). A higher prevalence of TPOAb (6/17=35.3%) was found in sera with high ICA titers (greater than or equal to 20 JDF-U), as compared to sera withlow ICA titers (5-19 JDF-U) and to ICA-negative sera (3/42=7,1%; chi (2)=5.4, p=0.02 and 258/2190=11,8%; chi (2)=6.8, p=0.009 respectively). Fourteenwomen (all ICA-negative) were diabetic: 4 had Type 1 and 10 had gestational DM; due to the low number, no correlation could be established between DMtype and TPOAb prevalence and/or titer. These preliminary data indicate that ATA are frequently observed in the general population of Sardinian pregnant women at term. As a consequence, even the frequency of postpartum thyroiditis is expected to be high. Although ATA were not increased in women with clinical overt diabetes, a higher prevalence of ATA was found in women with high titers of circulating ICA. Our results also confirm that Sardinia represents, perhaps for its peculiar genetic characteristics, an ideal placeto study organ-specific autoimmunity. (J. Endocrinol. Invest. 24: 570-574,2001) (C) 2001, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:06:11