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Titolo:
Physiological and anatomic evidence for functional subclasses of serotonergic raphe magnus cells
Autore:
Gao, K; Mason, P;
Indirizzi:
Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 rmacol & Physiol, Chicago, IL 60637 USA Univ Chicago, Comm Neurobiol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 , Comm Neurobiol, Chicago, IL 60637 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 4, volume: 439, anno: 2001,
pagine: 426 - 439
SICI:
0021-9967(20011029)439:4<426:PAAEFF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROMEDIAL MEDULLA; STEM RETICULOSPINAL NUCLEI; GAMMA-AMINOBUTYRIC ACID; FREELY MOVING CATS; LOCUS-COERULEUS; SPINAL-CORD; IMMUNOHISTOCHEMICAL EVIDENCE; PERIAQUEDUCTAL GRAY; NEURONAL MORPHOLOGY; RAT MEDULLA;
Keywords:
retroperitoneal; pain; visceral; nociceptive modulation; electrophysiology; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Mason, P Univ Chicago, Dept Neurobiol Pharmacol & Physiol, MC 0926,947 E 58th St, Chicago, IL 60637 USA Univ Chicago MC 0926,947 E 58th St Chicago ILUSA 60637 60637 USA
Citazione:
K. Gao e P. Mason, "Physiological and anatomic evidence for functional subclasses of serotonergic raphe magnus cells", J COMP NEUR, 439(4), 2001, pp. 426-439

Abstract

Serotonergic cells in the medullary nucleus raphe magnus (RM) and adjacentnucleus reticularis magnocellularis (NRMC) project to the spinal cord where they are likely to modulate nociceptive transmission. Previous studies have suggested that these cells are physiologically and anatomically heterogeneous. In the present investigation, we examined whether subclasses of serotonergic RM and NRMC cells can be delineated based on their response to a visceral stimulus, and whether any such subclasses are morphologically distinct. Most RM and NRMC serotonergic cells tested (81 of 116) responded to retraction of the descending aorta into a polyethylene tube (the snare stimulus) with 57% of all cells tested excited and 13% inhibited. Responses of serotonergic cells to the snare outlasted the stimulus, were not reflective of evoked cardiovascular changes, and were observed in sino-aortic deafferented rats, evidence that the snare stimulus does not influence serotonergic cell discharge through activation of baroreceptors. Because serotonergic cells responsive to the snare were also responsive to mechanical brushing within the retroperitoneum, the snare is likely to change serotonergic cell discharge by means of the activation of mechanosensitive visceral afferents. Intracellular labeling of physiologically characterized serotonergic RM andNRMC cells showed that cells that were responsive to the snare stimulus had simpler axonal collateralization patterns than cells that were unresponsive to the snare stimulus. This association between morphological and physiological properties provides additional evidence that subpopulations of serotonergic cells exist and serve varied physiological functions. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:42:37