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Titolo:
Clozapine enhances neurocognition and clinical symptomatology more than standard neuroleptics
Autore:
Potkin, SG; Fleming, K; Jin, Y; Gulasekaram, B;
Indirizzi:
Univ Calif Irvine, Med Ctr, Dept Psychiat & Human Behav, Orange, CA 92686 USA Univ Calif Irvine Orange CA USA 92686 & Human Behav, Orange, CA 92686 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 5, volume: 21, anno: 2001,
pagine: 479 - 483
SICI:
0271-0749(200110)21:5<479:CENACS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPSYCHOLOGICAL TEST-PERFORMANCE; CHRONIC-SCHIZOPHRENIC PATIENTS; PSYCHIATRIC-SYMPTOMS; COGNITIVE FUNCTIONS; NEGATIVE SYMPTOMS; MEMORY; MEDICATION; DEFICITS; CORTEX; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Fleming, K Univ Calif Irvine, Med Ctr, Dept Psychiat & Human Behav, 101 City Dr S, Orange, CA 92686 USA Univ Calif Irvine 101 City Dr S Orange CA USA92686 A 92686 USA
Citazione:
S.G. Potkin et al., "Clozapine enhances neurocognition and clinical symptomatology more than standard neuroleptics", J CL PSYCH, 21(5), 2001, pp. 479-483

Abstract

Neurocognition and clinical symptomatology were evaluated in 27 patients with schizophrenia during a double-blind, placebo-controlled, crossover study involving clozapine, an atypical antipsychotic agent, and haloperidol, a conventional neuroleptic. Patients were assessed 5 to 6 weeks after initiation of each phase. Clinical symptomatology, based on Brief Psychiatric Rating Scale and Scale for the Assessment of Negative Symptoms ratings, markedly improved after treatment with both haloperidol and clozapine. The beneficial effects of clozapine were statistically significantly greater than the effects from the haloperidol treatment. Regarding neurocognition, both agents proved efficacious in improving performance on nearly all measures compared with placebo. In addition, as compared with haloperidol, clozapine significantly improved performance on Trails B, Verbal Fluency, and measures ofdelayed verbal memory, and it tended to increase performance on most measures. Additional analyses indicated that the improvement on neurocognitive measures was not because of symptom amelioration; rather, neurocognitive deficits seem to be an intrinsic enduring feature of schizophrenia. The superiority of clozapine over haloperidol may be related to clozapine's unique psychopharmacologic profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 12:17:47