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Titolo:
Concomitant progressive multifocal leucoencephalopathy and primary centralnervous system lymphoma expressing JC virus oncogenic protein, large T antigen
Autore:
Gallia, GL; DelValle, L; Laine, C; Curtis, M; Khalili, K;
Indirizzi:
Temple Univ, Coll Sci & Technol, Ctr NeuroVirol & Canc Biol, Philadelphia,PA 19122 USA Temple Univ Philadelphia PA USA 19122 anc Biol, Philadelphia,PA 19122 USA Thomas Jefferson Univ, Jefferson Med Coll, Ctr Res Med Educ & Healthcare, Dept Med,Div Internal Med, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 5, volume: 54, anno: 2001,
pagine: 354 - 359
SICI:
1366-8714(200110)54:5<354:CPMLAP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; IMMUNE-DEFICIENCY SYNDROME; SYNDROME AIDS; CHROMOSOMAL DAMAGE; HIV-INFECTION; EPSTEIN-BARR; LEUKOENCEPHALOPATHY; NEUROPATHOLOGY; BRAIN; PATHOGENESIS;
Keywords:
JC virus; progressive multifocal leucoencephalopathy; primary central nervous system lymphoma; acquired immunodeficiency syndrome; demyelination; T antigen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Khalili, K Temple Univ, Coll Sci & Technol, Ctr NeuroVirol & Canc Biol, 1900 N 12th St,Room 203, Philadelphia, PA 19122 USA Temple Univ 1900 N 12th St,Room 203 Philadelphia PA USA 19122 A
Citazione:
G.L. Gallia et al., "Concomitant progressive multifocal leucoencephalopathy and primary centralnervous system lymphoma expressing JC virus oncogenic protein, large T antigen", J CL PATH-M, 54(5), 2001, pp. 354-359

Abstract

This report describes the concomitant occurrence of the JC virus (JCV) induced demyelinating disease progressive multifocal leucoencephalopathy (PML)and a primary central nervous system lymphoma (PCNS-L) in a patient with AIDS. Postmortem neuropathological examination revealed characteristic features of PML including multiple lesions of demyelination, enlarged oligodendrocytes with hyperchromatic nuclei (many containing eosinophilic intranuclear inclusions), and enlarged astrocytes with bizarre hyperchromatic nuclei. Immunohistochemical analysis demonstrated the expression of the JCV capsid protein VP-1 in the nuclei of infected oligodendrocytes and astrocytes. ThePCNS-L lesion located in the basal ganglia was highly cellular, distributed perivascularly, and consisted of large atypical plasmacytoid lymphocytes. Immunohistochemical examination of this neoplasm identified it to be of B cell origin. Moreover, expression of the JCV oncogenic protein, T antigen, was detected in the nuclei of the neoplastic lymphocytes. This study provides the first evidence for a possible association between JCV and PCNS-L.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 21:09:46