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Titolo:
The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors
Autore:
Vilmos, P; Gaudenz, K; Hegedus, Z; Marsh, JL;
Indirizzi:
Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 v & Cell Biol, Irvine, CA 92697 USA Hungarian Acad Sci, Biol Res Ctr, Mol Modelling Lab, H-6701 Szeged, Hungary Hungarian Acad Sci Szeged Hungary H-6701 ing Lab, H-6701 Szeged, Hungary
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 5, volume: 54, anno: 2001,
pagine: 317 - 323
SICI:
1366-8714(200110)54:5<317:TTGFOP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BINDING; DROSOPHILA INSULIN-RECEPTOR; LUNG EPITHELIAL-CELLS; BREAST-CANCER CELLS; C-TERMINAL DOMAIN; LARVAL CUTICLE; ZYGOTIC LOCI; PATTERN-FORMATION; GENE; IDENTIFICATION;
Keywords:
twisted gastrulation; insulin-like growth factor binding protein; CCN; tsg;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Marsh, JL Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 iol, Irvine, CA 92697 USA
Citazione:
P. Vilmos et al., "The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors", J CL PATH-M, 54(5), 2001, pp. 317-323

Abstract

Aims-To analyse the similarities between the Twisted gastrulation (TSG) proteins known to date; in addition, to determine phylogenetic relations among the TSG proteins, and between the TSGs and other protein families-the CCN(for example, CCN2 (CTGF), CCN1 (CYR61), and CCN3 (NOV)) and IGFBP (insulin-like growth factor binding protein) families. Methods-TBLASTN and FASTA3 were used to identify new tsg genes and relatives of the TSG family. The sequences were aligned with ClustalW. The predictions of sites for signal peptide cleavage, post-translational modifications, and putative protein domains were carried out with software available at various databases. Unrooted phylogenetic trees were calculated using the UPGMA, method. Results-Several tsg genes from vertebrates and invertebrates were compared. Alignment of protein sequences revealed a highly conserved family of TSG proteins present in both vertebrates and invertebrates, whereas the slightly less well conserved IGFBP and CCN proteins are apparently present only invertebrates. The TSG proteins display strong homology among themselves andthey are composed of a putative signal peptide at the N-terminus followed by a cysteine rich (CR) region, a conserved domain devoid of cysteines, a variable midregion, and a C-terminal CR region. The most striking similaritybetween the TSGs and the IGFBP and CCN proteins occurs in the N-terminal conserved cysteine rich domain and the characteristic 5' cysteine rich domain(s), spacer region, and 3' cysteine rich domain structure. Conclusion-The family of highly conserved TSG proteins, together with the IGFBP and CCN families, constitute an emerging multigene superfamily of secreted cysteine rich factors. The TSG branch of the superfamily appears to predate the others because it is present in all species examined, whereas the CCN and IGFBP genes are found only in vertebrates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:46:14