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Titolo:
Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features
Autore:
Martinez, A; Walker, RA; Shaw, JA; Dearing, SJ; Maher, ER; Latif, F;
Indirizzi:
Univ Birmingham, Sch Med, Dept Paediat & Child Hlth, Sect Med & Mol Genet,Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Univ Leicester, Glenfield Gen Hosp, Breast Canc Res Unit, Leicester LE3 9QP, Leics, England Univ Leicester Leicester Leics England LE3 9QP er LE3 9QP, Leics, England
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 5, volume: 54, anno: 2001,
pagine: 300 - 306
SICI:
1366-8714(200110)54:5<300:C3ALIE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; RENAL-CELL CARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; LUNG-CANCER; HOMOZYGOUS DELETION; HISTOLOGICAL GRADE; OVARIAN-CANCER; SHORT ARM; LOCUS; REGION;
Keywords:
chromosome 3p; tumour suppressor genes; early invasive breast cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Latif, F Univ Birmingham, Sch Med, Dept Paediat & Child Hlth, Sect Med & Mol Genet,Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT s, England
Citazione:
A. Martinez et al., "Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features", J CL PATH-M, 54(5), 2001, pp. 300-306

Abstract

Aims-Chromosome 3p allele loss is a frequent event in many common sporadiccancers including lung, breast, kidney, ovarian, and head and neck cancer. To analyse the extent and frequency of 3p allelic losses in T1N0 and T1N1 invasive sporadic breast cancer, 19 microsatellite markers spread along 3p were analysed in 40 such breast carcinomas with known clinicopathological parameters. Methods-Loss of heterozygosity analysis was carried out using 3p microsatellite markers that were non-randomly distributed and chosen to represent regions that show hemizygous and/or homozygous losses in lung cancer (lung cancer tumour suppressor gene region 1 ( LCTSGR1) at 3p21.3 and LCTSGR2 at 3p12), and regions demonstrating suppression of tumorigenicity in breast, kidney, lung, and ovarian cancer. Results-Allelic loss was seen at one or more loci in 22 of these clinically early stage sporadic breast tumours, but none had complete 3p allele loss. Several regions with non-overlapping deletions were defined, namely: (1) IS tumours showed loss at 3p21-22, a physical distance of 12 Mb; (2) 11 tumours showed loss at 3p 12 within a physical distance of I Mb, this region is contained within LCTSGR2; (3) six tumours showed loss at 3p25-24, including the von Hippel-Lindau (VHL) locus; (4) five tumours showed loss at 3p14.2, including the fragile histidine triad (FHIT) locus. Conclusions-This is the largest study to date defining the extent and range of 3p allelic losses in early stage invasive breast cancer and the results indicate that region 3p21-22 containing LCTSGR1 and a region at 3p12 within LCTSGR2 are the most frequent sites of 3p allelic loss in these breast carcinomas. This suggests that tumour suppressor genes located in these regions may play important roles in the development of breast cancer. There wasan association between increasing 3p allelic loss and increasing tumour grade and loss of progesterone (p = 0.0098) and oestrogen (p = 0.0472) receptor expression, indicating a link between 3p allelic loss and the regulationof differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:52:02