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Titolo:
Transthyretin values correlate with mucosal recovery in patients with coeliac disease taking a gluten free diet
Autore:
McMillan, SA; Dickey, W; Douglas, JP; Hughes, DF;
Indirizzi:
Royal Grp Hosp, Reg Immunol Serv, Belfast BT12 6BN, Antrim, North Ireland Royal Grp Hosp Belfast Antrim North Ireland BT12 6BN ntrim, North Ireland Altnagelvin Hosp, Dept Gastroenterol, Londonderry BT47 6SB, North Ireland Altnagelvin Hosp Londonderry North Ireland BT47 6SB 7 6SB, North Ireland Altnagelvin Hosp, Dept Histopathol, Londonderry BT47 6SB, North Ireland Altnagelvin Hosp Londonderry North Ireland BT47 6SB 7 6SB, North Ireland
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY
fascicolo: 10, volume: 54, anno: 2001,
pagine: 783 - 786
SICI:
0021-9746(200110)54:10<783:TVCWMR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM TRANSFERRIN RECEPTOR; CELIAC-DISEASE; IRON-DEFICIENCY; FOLLOW-UP; MALNUTRITION; SENSITIVITY; ANTIBODIES; SPRUE;
Keywords:
coeliac disease; transthyretin; nutrition; villous atrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: McMillan, SA Royal Grp Hosp, Reg Immunol Serv, Belfast BT12 6BN, Antrim, North Ireland Royal Grp Hosp Belfast Antrim North Ireland BT12 6BN Ireland
Citazione:
S.A. McMillan et al., "Transthyretin values correlate with mucosal recovery in patients with coeliac disease taking a gluten free diet", J CLIN PATH, 54(10), 2001, pp. 783-786

Abstract

Aims-To assess changes in indicators of nutrition and iron deficiency as possible non-invasive markers of mucosal recovery in patients with coeliac disease on a gluten free diet. Methods-Concentrations of transthyretin, retinol binding protein, soluble transferrin receptor, IgA anti-gliadin, and IgA and-transglutaminase, and titres of IgA anti-endomysial antibody were measured in 36 newly diagnosed adult patients with coeliac disease and duodenal villous atrophy before (T0)and after one year (T1) on a gluten free diet. Duodenal biopsies taken at T0 and T1 were compared and graded as no improvement (no change in initial grade of villous atrophy) or improvement. Results-Twenty two patients showed histological improvement and 14 showed no improvement. Transthyretin values increased in all patients with mucosalimprovement and decreased in all patients showing no improvement. However,transthyretin values did not correlate with the degree of villous atrophy at T0 and T1 when assessed separately. Changes in retinol binding protein and soluble transferrin receptor values did not correlate with mucosal improvement. Coeliac disease associated antibodies (to gliadin, endomysium, and transglutaminase) decreased in most patients between T0 and T1, irrespective of mucosal recovery. Conclusions-Serial but not single measurements of transthyretin may be used as a non-invasive test to monitor mucosal recovery and therefore reduce the need for, or frequency of, follow up biopsies in treated patients with coeliac disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:10:03