Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Delayed, but marked, expression of apolipoprotein E is involved in tissue clearance after cerebral infarction
Autore:
Kitagawa, K; Matsumoto, M; Kuwabara, K; Ohtsuki, T; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 peut A8, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 10, volume: 21, anno: 2001,
pagine: 1199 - 1207
SICI:
0271-678X(200110)21:10<1199:DBMEOA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MONOCYTE-DERIVED MACROPHAGES; TRANSIENT FOREBRAIN ISCHEMIA; E MESSENGER-RNA; ALZHEIMERS-DISEASE; E IMMUNOREACTIVITY; CHOLESTEROL TRANSPORT; GLOBAL-ISCHEMIA; APOPROTEIN-E; RAT;
Keywords:
apolipoprotein E; ischemia; knockout mice; macrophage; tissue remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kitagawa, K Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, 2-2 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
K. Kitagawa et al., "Delayed, but marked, expression of apolipoprotein E is involved in tissue clearance after cerebral infarction", J CEREBR B, 21(10), 2001, pp. 1199-1207

Abstract

Clearance of infarct tissue would be an important process for tissue repair after a stroke. Delayed clearance may hamper reconstitution of the blood-brain barrier and glial boundary formation. Recent growing evidence has indicated that apolipoprotein E (APOE), a major apoprotein, plays an importantrole in lipid transport and homeostasis in the brain. The tissue in the infarction contains abundant lipids must be removed for tissue clearance. In the current study, the authors investigated APOE expression after focal ischemia and the functional role of APOE in tissue clearance using APOE-knockout mice. Expression of APOE was delayed, but marked, in immunohistochemistry and immunoblotting 7 days after permanent focal ischemia. Macrophages were found to express APOE in the infarct center. Infarct size was similar after focal ischemia between wild-type and APOE-knockout mice, although there was no APOE protein expression in knockout mice. However, clearance of infarct tissue 2 weeks after ischemia was significantly delayed in APOE-knockout mice compared with wild-type mice. The current study supports current thinking that APOE is a key molecule for tissue remodeling in the brain. Clearance of damaged tissue may be one of the important functions of APOE in thebrain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:41:43