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Titolo:
Plague vaccine research and development
Autore:
Williamson, ED;
Indirizzi:
DSTL, Salisbury, Wilts, England DSTL Salisbury Wilts EnglandDSTL, Salisbury, Wilts, England
Titolo Testata:
JOURNAL OF APPLIED MICROBIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 606 - 608
SICI:
1364-5072(200110)91:4<606:PVRAD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
YERSINIA-PESTIS; F1 ANTIGEN; PROTECTION; SURFACE; MOUSE; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Williamson, ED CBD Sector, Porton Down, Salisbury SP4 0JQ, Wilts, England CBD Sector Porton Down Salisbury Wilts England SP4 0JQ land
Citazione:
E.D. Williamson, "Plague vaccine research and development", J APPL MICR, 91(4), 2001, pp. 606-608

Abstract

A fully recombinant subunit vaccine is described which provides enhanced protection against bubonic plague and a new prophylactic against the pneumonic form of the disease. The vaccine comprises two subunit antigens termed F1 and V which are individually immunogenic and protective and have additiveprotective effect in combination. The vaccines has been demonstrated efficacious in small animal models, including a strain of mice with a targeted gene deletion for interleukin 4 (IL4T mice). The mechanism of protection conferred by the vaccine is principally antibody-mediated and antibody titre to F1 + V in the mouse correlates with protection. Surrogate markers of efficacy in man have been identified and will be applied to support clinical trialling of the vaccine. This vaccine could be used to counter bubonic and pneumonic plague in areas of the world where the disease is endemic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:24:44