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Titolo:
SPECT and neuropsychological performance in severe depression treated withECT
Autore:
Mervaala, E; Kononen, M; Fohr, J; Husso-Saastamoinen, M; Valkonen-Korhonen, M; Kuikka, JT; Viinamaki, H; Tammi, AK; Tiihonen, J; Partanen, J; Lehtonen, J;
Indirizzi:
Kuopio Univ Hosp, Dept Clin Neurophysiol, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 ysiol, SF-70210 Kuopio, Finland Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 chiat, SF-70210 Kuopio, Finland Kuopio Univ Hosp, Dept Clin Physiol, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 ysiol, SF-70210 Kuopio, Finland Kuopio Univ Hosp, Dept Forens Psychiat, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 chiat, SF-70210 Kuopio, Finland
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1, volume: 66, anno: 2001,
pagine: 47 - 58
SICI:
0165-0327(200109)66:1<47:SANPIS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; PHOTON-EMISSION-TOMOGRAPHY; MAJOR DEPRESSION; ELECTROCONVULSIVE-THERAPY; UNIPOLAR DEPRESSION; BRAIN ACTIVITY; HMPAO SPECT; COMPUTED-TOMOGRAPHY; ALZHEIMERS-DISEASE; COTARDS-SYNDROME;
Keywords:
ECT; SPECT; rCBF; iomazenil; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Mervaala, E Kuopio Univ Hosp, Dept Clin Neurophysiol, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 210 Kuopio, Finland
Citazione:
E. Mervaala et al., "SPECT and neuropsychological performance in severe depression treated withECT", J AFFECT D, 66(1), 2001, pp. 47-58

Abstract

Background: In severe depression, studies of regional cerebral blood flow (rCBF) by SPECT have not produced uniform results. The association between changes in SPECT and electroconvulsive therapy (ECT) has shown somewhat conflicting data. No data are available on benzodiazepine receptor function SPECT studies in ECT. Methods: Twenty drug-resistant adult inpatients fulfilling the DSM-IIIR criteria for major depression were studied by SPECT (rCBF by relative ECD uptake in all, and benzodiazepine receptor function by iomazenil uptake in five subjects) before and I week after clinically successful bitemporal ECT. Clinical and neuropsychological test scores were used as references for the possible changes in SPECT. Results: An increased perfusion after ECT was observed in right temporal and bilateral parietal cortices, whereas no reductions in relative ECD uptake were seen after ECT. Iomazenil-SPECT revealed a highly significant increase in the benzodiazepine receptor uptake in all studied cortical regions except temporal cortices. Conclusions: Clinically successful ECT was associated with changes in vascular perfusion and GABAergic neurotransmission, providing new evidence for the mechanism of action of ECT and for the neurobiology of severe drug-resistant depression. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:44:41