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Titolo:
Serotonin and bipolar disorder
Autore:
Mahmood, T; Silverstone, T;
Indirizzi:
Univ Otago, Dunedin Sch Med, Dept Psychol Med, Dunedin, New Zealand Univ Otago Dunedin New Zealand , Dept Psychol Med, Dunedin, New Zealand
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1, volume: 66, anno: 2001,
pagine: 1 - 11
SICI:
0165-0327(200109)66:1<1:SABD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CSF MONOAMINE METABOLITES; MANIC-DEPRESSIVE ILLNESS; TRANSPORTER GENE; RECEPTOR GENE; FENFLURAMINE CHALLENGE; BEHAVIORAL-RESPONSES; ASSOCIATION ANALYSIS; CORTISOL RESPONSES; NEURO-ENDOCRINE; 5-HT2C RECEPTOR;
Keywords:
serotonin; 5-HT; bipolar;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Mahmood, T Dunedin Publ Hosp, Healthcare Otago, Mental Hlth Serv, Dunedin,New Zealand Dunedin Publ Hosp Dunedin New Zealand , Dunedin, New Zealand
Citazione:
T. Mahmood e T. Silverstone, "Serotonin and bipolar disorder", J AFFECT D, 66(1), 2001, pp. 1-11

Abstract

With the emergence of specific pharmacological probes for various serotonin (5-HT) receptors and radio-ligands for central 5-HT, it has now become possible to investigate its role in the pathogenesis of bipolar disorder moreclosely. This paper critically reviews the scientific literature regardingthe relationship between bipolar disorder and sertonergic systems. The evidence suggests that central serotonergic activity is reduced in the depressive phase of bipolar disorder. Similar findings have been reported in bipolar patients when euthymic, indicating that that lower 5-HT activity could be a trait marker for bipolar disorder. Findings reported in the manic phaseof this illness are inconsistent. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:30:32