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Titolo:
Evaluation of FASTPlaqueTB-RIF (TM), a rapid, manual test for the determination of rifampicin resistance from Mycobacterium tuberculosis cultures
Autore:
Albert, H; Heydenrych, A; Mole, R; Trollip, A; Blumberg, L;
Indirizzi:
S African Inst Med Res, TB Lab, Biotec Labs Ltd, ZA-2000 Johannesburg, South Africa S African Inst Med Res Johannesburg South Africa ZA-2000 g, South Africa Biotec Labs Ltd, Ipswich, Suffolk, England Biotec Labs Ltd Ipswich Suffolk England s Ltd, Ipswich, Suffolk, England
Titolo Testata:
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
fascicolo: 10, volume: 5, anno: 2001,
pagine: 906 - 911
SICI:
1027-3719(200110)5:10<906:EOF(AR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOMETRIC METHOD; SUSCEPTIBILITY; STREPTOMYCIN; ASSAY;
Keywords:
rifampicin; mycobacteriophage; susceptibility test; tuberculosis; resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Albert, H S African Inst Med Res, TB Lab, Biotec Labs Ltd, Hosp & De KorteSt,POB 1038, ZA-2000 Johannesburg, South Africa S African Inst Med Res Hosp & De Korte St,POB 1038 Johannesburg South Africa ZA-2000
Citazione:
H. Albert et al., "Evaluation of FASTPlaqueTB-RIF (TM), a rapid, manual test for the determination of rifampicin resistance from Mycobacterium tuberculosis cultures", INT J TUBE, 5(10), 2001, pp. 906-911

Abstract

SETTING: Two Mycobacteriology Reference Laboratories in Johannesburg (Laboratory 1) and Cape Town (Laboratory 2), South Africa. OBJECTIVE: To determine the ability of the FAST- PlaqueTB-RIF (TM) test tocorrectly identify rifampicin susceptibility on strains of Mycobacterium tuberculosis cultured on solid media. DESIGN: A comparative study of FASTPlaqueTB-RIF (TM) and conventional drugsusceptibility methods, with selection bias to include sufficient rifampicin resistant strains. RESULTS: Rifampicin susceptibility results were available for 191 strains of M. tuberculosis. Eighty-one strains were found to be rifampicin resistant and 110 strains were rifampicin susceptible by conventional methods. The sensitivity, specificity and overall accuracy for the FASTPlaqueTB-RIF (TM)were 100%, 97% and 98% at Laboratory 1, and 100%, 94% and 97% at Laboratory 2. CONCLUSION: FASTPlaqueTB-RIF (TM) offers a performance comparable to the gold standard proportion methods of rifampicin susceptibility testing, as well as the advantage of the speed of results that the newer methods deliver,without the need for specialised equipment. This makes FASTPlaqueTB-RIF (TM) a rapid test for rifampicin resistance suitable for widespread application.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:42:06