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Titolo:
The pharmacology of human working memory
Autore:
Ellis, KA; Nathan, PJ;
Indirizzi:
Swinburne Univ Technol, Brain Sci Inst, Neuropharmacol Lab, Hawthorn, Vic 3122, Australia Swinburne Univ Technol Hawthorn Vic Australia 3122 n, Vic 3122, Australia
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 299 - 313
SICI:
1461-1457(200109)4:3<299:TPOHWM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE CEREBRAL-CORTEX; DELAYED-RESPONSE TASK; MONKEY PREFRONTAL CORTEX; OBJECT RECOGNITION TASK; DOPAMINE D1 RECEPTORS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; NEURONAL-ACTIVITY; INTRASEPTAL INFUSIONS; ANTIPSYCHOTIC-DRUGS;
Keywords:
acetylcholine; dopamine; human working memory; pharmacology; serotonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Nathan, PJ Swinburne Univ Technol, Brain Sci Inst, Neuropharmacol Lab, 400Burwood Rd, Hawthorn, Vic 3122, Australia Swinburne Univ Technol 400 Burwood Rd Hawthorn Vic Australia 3122
Citazione:
K.A. Ellis e P.J. Nathan, "The pharmacology of human working memory", IN J NEUROP, 4(3), 2001, pp. 299-313

Abstract

Experimental studies conducted primarily on non-human primates have begun to address the anatomical and neurochemical correlates of working memory. There is an associated growing body of experimental literature investigatingwhether modulating key neurotransmitters can facilitate working memory in humans. This paper reviews evidence that acute modulation of dopamine in particular, but also noradrenaline, acetylcholine and serotonin may influenceworking-memory performance in humans. Differences in neurochemical specificity with regard to stages of working memory, type of working memory (spatial or non-spatial) and cortical effects are also discussed. This evidence has contributed to neuropharmacological understanding of working memory in humans. The important therapeutic consequences of a better understanding of facilitation of working memory is discussed in reference to schizophrenia, Parkinson's disease and Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:49:09