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Titolo:
Lack of association between GABRA3 and unipolar affective disorder: a multicentre study
Autore:
Massat, I; Souery, D; Del-Favero, J; Oruc, L; Jakovljevic, M; Folnegovic, V; Adolfsson, R; Kaneva, R; Papadimitriou, G; Dikeos, D; Jazin, E; Milanova, V; Van Broeckhoven, C; Mendlewicz, J;
Indirizzi:
Free Univ Brussels, Erasme Hosp, Univ Clin Brussels, Dept Psychiat, B-1070Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 hiat, B-1070Brussels, Belgium Univ Antwerp, VIB, Flanders Interuniv Inst Biotechnol, Dept Mol Genet, B-2020 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2020 t Mol Genet, B-2020 Antwerp, Belgium Univ Sarajevo, Psychiat Clin, Sarajevo 71000, Bosnia & Herceg Univ Sarajevo Sarajevo Bosnia & Herceg 71000 jevo 71000, Bosnia & Herceg Umea Univ, Dept Psychiat, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Univ, Dept Psychiat, S-90187 Umea, Sweden Med Univ Sofia, Univ Hosp Obstet, Lab Mol Pathol, Sofia, Bulgaria Med UnivSofia Sofia Bulgaria p Obstet, Lab Mol Pathol, Sofia, Bulgaria Univ Athens, Sch Med, Dept Psychiat, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 ept Psychiat, GR-11527 Athens, Greece Univ Athens, Mental Hlth Res Inst, Athens, Greece Univ Athens Athens Greece Athens, Mental Hlth Res Inst, Athens, Greece Biomed Ctr, Dept Med Genet, S-75123 Uppsala, Sweden Biomed Ctr Uppsala Sweden S-75123 ept Med Genet, S-75123 Uppsala, Sweden Alexandra Univ Hosp, Dept Psychiat, Psychiat Clin 1, Sofia, Bulgaria Alexandra Univ Hosp Sofia Bulgaria at, Psychiat Clin 1, Sofia, Bulgaria
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 273 - 278
SICI:
1461-1457(200109)4:3<273:LOABGA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR DISORDER; PLASMA GABA; ILLNESS; LINKAGE; SCHIZOPHRENIA; DEPRESSION; MARKERS; SCAN; GENE;
Keywords:
association study; candidate gene; chromosome X; GABRA3; unipolar disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Massat, I Free Univ Brussels, Erasme Hosp, Univ Clin Brussels, Dept Psychiat, 808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels 808 RouteLennik Brussels Belgium B-1070 ium
Citazione:
I. Massat et al., "Lack of association between GABRA3 and unipolar affective disorder: a multicentre study", IN J NEUROP, 4(3), 2001, pp. 273-278

Abstract

Available data on gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in the brain GABAergic system activity contributes to vulnerability to affective disorders (AD), including bipolar disorder (BPAD) and unipolar disorder (UPAD). The localization of the alpha3 subunit GABA receptor (GABRA3) gene in Xq28, a region of interest for BPAD suggests that GABRA3 may be a relevant candidate gene. In the present study, we tested thegenetic contribution of the GABRA3 dinucleotide polymorphism in a Europeanmulticentre UPAD case-control sample [UPAD (n = 106), controls (n = 212)]. Our negative results suggest that GABRA3 does not confer susceptibility nor is it in linkage disequilibrium with another close gene involved in the genetic aetiology of UPAD.

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Documento generato il 18/01/20 alle ore 13:05:41