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Titolo:
Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder
Autore:
Camarena, B; Rinetti, G; Cruz, C; Hernandez, S; de la Fuente, JR; Nicolini, H;
Indirizzi:
Inst Nacl Psiquitria Ramon Fuente Muniz, Dept Genet Psiquiatr, Mexico City14370, DF, Mexico Inst Nacl Psiquitria Ramon Fuente Muniz Mexico City DF Mexico 14370 exico Univ Nacl Autonoma Mexico, Mexico City 14370, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 14370 y 14370, DF, Mexico
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 269 - 272
SICI:
1461-1457(200109)4:3<269:ASOTST>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGULATORY REGION; 5-HTTLPR; SLC6A4; RISK;
Keywords:
association study; family-based method; OCD; serotonin transporter gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nicolini, H Inst Nacl Psiquitria Ramon Fuente Muniz, Dept Genet Psiquiatr,Mexico City14370, DF, Mexico Inst Nacl Psiquitria Ramon Fuente Muniz Mexico City DF Mexico 14370
Citazione:
B. Camarena et al., "Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder", IN J NEUROP, 4(3), 2001, pp. 269-272

Abstract

The hypothesis implicating the serotonergic system in the pathophysiology of obsessive-compulsive disorder (OCD) is supported by the therapeutic efficacy of selective serotonin reuptake inhibitors (SSRIs). Since SSRIs act onthe serotonin transporter (5-HTT), it has been suggested that the 5-HTT gene (SCL6A4) could be a good candidate for OCD. The SCL6A4 gene has a 44-bp insertion/deletion polymorphism in its promoter region (5-HTTLPR). Previousstudies have revealed an association between OCD and the I allele. We analysed the 5HTTLPR polymorphic system in 115 Mexican OCD patients and 136 controls. No significant association was found between I allele and OCD (chi (2) = 1.54, d.f. = 1, p = 0.21). Furthermore, we assessed alternative methods that employ family-based designs in a sample of 43 trios. Haplotype-basedhaplotype relative risk and transmission disequilibrium analysis did not show a preferential transmission of I allele to OCD probands. Our results indicate the need to analyse larger samples using family-based methods.

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Documento generato il 05/04/20 alle ore 06:39:41