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Titolo:
Analysis of neurosteroid levels in attention deficit hyperactivity disorder
Autore:
Strous, RD; Spivak, B; Yoran-Hegesh, R; Maayan, R; Averbuch, E; Kotler, M; Mester, R; Weizman, A;
Indirizzi:
Beer Yaakov Mental Hlth Ctr, IL-70350 Beer Yaagov, Israel Beer Yaakov Mental Hlth Ctr Beer Yaagov Israel IL-70350 r Yaagov, Israel Ness Ziona Mental Hlth Ctr, IL-74100 Ness Ziona, Israel Ness Ziona Mental Hlth Ctr Ness Ziona Israel IL-74100 Ness Ziona, Israel Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel Felsentein Med Res Ctr, Lab Biol Psychiat, Petah Tiqwa, Israel Felsentein Med Res Ctr Petah Tiqwa Israel Psychiat, Petah Tiqwa, Israel Ben Gurion Univ Negev, Fac Med, IL-49100 Petah Tiqwa, Israel Ben Gurion Univ Negev Petah Tiqwa Israel IL-49100 00 Petah Tiqwa, Israel Geha Psychiat Hosp, Res Unit, IL-49100 Petah Tiqwa, Israel Geha Psychiat Hosp Petah Tiqwa Israel IL-49100 49100 Petah Tiqwa, Israel
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 259 - 264
SICI:
1461-1457(200109)4:3<259:AONLIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROEPIANDROSTERONE-SULFATE; NEUROACTIVE STEROIDS; SIGMA-RECEPTORS; BRAIN; MECHANISM; MEMORY; MICE;
Keywords:
ADHD; dehydroepiandrosterone; dehydroepiandrosterone sulphate; GABA(A); neurosteroids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Strous, RD Beer Yaakov Mental Hlth Ctr, POB 1, IL-70350 Beer Yaagov, Israel Beer Yaakov Mental Hlth Ctr POB 1 Beer Yaagov Israel IL-70350
Citazione:
R.D. Strous et al., "Analysis of neurosteroid levels in attention deficit hyperactivity disorder", IN J NEUROP, 4(3), 2001, pp. 259-264

Abstract

Neurosteroids are important neuroactive substrates with demonstrated involvement in several neurophysiological and disease processes. Attention deficit hyperactivity disorder (ADHD) has been associated with dysregulation of the catecholaminergic and serotonergic systems, however its relationship toirregularities or changes in neurosteroid levels remains unknown. We examined the relationship between blood levels of dehydroepiandrosterone (DHEA),its principal precursor pregnenolone and its principal metabolite dehydroepiandrosterone sulphate (DHEAS) in 29 young male subjects aged 7-15 years with DSM-lV criteria of ADHD. Subjects were evaluated by a specially designed scale, following which patients were divided into two groups according toseverity of symptomatology. Results indicated significant inverse correlations between clinical symptomatology and levels of DHEA and pregnenolone inthe total group. These inverse correlations were particularly evident in the less severe group of subjects. Levels of DHEA and DHEAS were inversely correlated with the hyperactivity subscale. Furthermore, using median blood levels as a cut-off indicator, higher blood levels of DHEA and DHEAS were associated with fewer ADHD symptoms, in particular hyperactivity symptomatology. Our findings suggest a possible protective effect of various neurosteroids on the expression of ADHD symptomatology.

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Documento generato il 18/01/20 alle ore 21:27:53