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Titolo:
Taijin kyofusho: a form of social anxiety disorder that responds to serotonin reuptake inhibitors
Autore:
Matsunaga, H; Kiriike, N; Matsui, T; Iwasaki, Y; Stein, DJ;
Indirizzi:
Osaka City Univ, Sch Med, Dept Neuropsychiat, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 hiat, Abeno Ku, Osaka 5458585, Japan Univ Stellenbosch, MRC, Unit Anxiety Disorders, Cape Town, South Africa Univ Stellenbosch Cape Town South Africa rders, Cape Town, South Africa Univ Florida, Gainesville, FL USA Univ Florida Gainesville FL USAUniv Florida, Gainesville, FL USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 231 - 237
SICI:
1461-1457(200109)4:3<231:TKAFOS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; PHOBIA; PLACEBO;
Keywords:
pharmacotherapy; serotonin reuptake inhibitors; taijin kyofusho;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Matsunaga, H Osaka City Univ, Sch Med, Dept Neuropsychiat, Abeno Ku, 1-4-3Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 , Japan
Citazione:
H. Matsunaga et al., "Taijin kyofusho: a form of social anxiety disorder that responds to serotonin reuptake inhibitors", IN J NEUROP, 4(3), 2001, pp. 231-237

Abstract

Taijin kyofusho (TKS) has been categorized as a 'culture-bound' illness that is unique to the East, although an alternative view holds that some TKS patients are best conceptualized as having a form of social anxiety disorder (SAD). However, pharmacotherapeutic interventions for TKS have not yet been rigorously investigated. A review was undertaken of 48 TKS patients initially treated with serotonin reuptake inhibitors (SRIs) in an outpatient setting of a Japanese hospital, Psychiatric diagnoses were determined according to DSM-IV, and a set of TKS diagnostic criteria based on a modification of DSM-IV SAD criteria. In addition, response to SRIs (clomipramine and fluvoxamine) was evaluated retrospectively using the Clinical Global Impressions (CGI) scale. All 48 patients met SAD-based TKS diagnostic criteria. In the pretreatment assessment, DSM-IV Axis I diagnoses included SAD (38%), major depressive episode (27%), and delusional disorder somatic type (15%). Sixteen (48%) of 33 patients treated with clomipramine or fluvoxamine for at least 6 months were categorized as responders (CGI = 1 or 2). Compared to responders, non-responders were significantly less likely to have pretreatment major depression, and significantly more likely to have comorbid clusterA personality disorders and to have received augmentation with antipsychotic drugs. Although TKS may be a heterogeneous condition with various comorbidities, patients invariably fulfilled diagnostic criteria for TKS based onSAD criteria. SRIs may be effective for a substantial number of TKS patients. Prospective controlled trials are necessary to confirm these findings and to delineate the pharmacotherapeutic profile of TKS.

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Documento generato il 21/01/20 alle ore 01:30:34