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Titolo:
Clinicopathologic and immunohistochemical features and microsatellite status of endometrial cancer of the uterine isthmus
Autore:
Watanabe, Y; Nakajima, H; Nozaki, K; Ueda, H; Obata, K; Hoshiai, H; Noda, K;
Indirizzi:
Kinki Univ, Sch Med, Dept Obstet & Gynecol, Osaka 5898511, Japan Kinki Univ Osaka Japan 5898511 pt Obstet & Gynecol, Osaka 5898511, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 368 - 373
SICI:
0277-1691(200110)20:4<368:CAIFAM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; P53 PROTEIN OVEREXPRESSION; PAPILLARY SEROUS CARCINOMA; DNA CONTENT; PROGNOSTIC FACTOR; PTEN MUTATIONS; BREAST-CANCER; COLON-CANCER; INSTABILITY; RECEPTOR;
Keywords:
uterine isthmic endometrial cancer; microsatellite instability; p53; estrogen receptor; progesterone receptor; DNA ploidy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, Y Kinki Univ, Sch Med, Dept Obstet & Gynecol, 377-2 Ohno Higashi, Osaka 5898511, Japan Kinki Univ 377-2 Ohno Higashi Osaka Japan 5898511 8511, Japan
Citazione:
Y. Watanabe et al., "Clinicopathologic and immunohistochemical features and microsatellite status of endometrial cancer of the uterine isthmus", INT J GYN P, 20(4), 2001, pp. 368-373

Abstract

To clarify the clinicopathologic, molecular, and immunohistochemical characteristics of uterine isthmic endometrial cancer (UIE), we examined 13 cases of UIE and compared them with 33 cases of endometrial cancer of the uterine corpus (UCE) with respect to clinicopathologic factors, the expression of p53, the estrogen receptor (ER) and the progesterone receptor (PR) status, DNA ploidy, and microsatellite instability (MSI). Five (38.4%) of the UIEpatients had stage I, two (15.4%) had stage II, and six (46.2%) had stage III disease (FIGO 1988). Myometrial invasion was confirmed in 92.3% of the UIE patients, and these patients had a higher (p <0.05) frequency of > 50% myometrial invasion (46.2%) than the patients with UCE (15.2%). Moreover, the UIE patients had a higher frequency of positive peritoneal cytology (p <0.05) and pelvic lymph node metastases (p <0.05). No UIE tumors exhibited MSI, and the tumors in these patients had a higher expression of p53 (p <0.01), a lower expression of ER (p <0.05) and PR (p <0.05), and a higher frequency of DNA aneuploidy (p <0.01) than the UCE tumors. These findings suggest that the UIE is clearly different from UCE in the clinicopathologic, immunohistochemical features, and microsatellite status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:58:01