Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pioglitazone: mechanism of action
Autore:
Smith, U;
Indirizzi:
Univ Gothenburg, Dept Internal Med, Lundberg Lab Diabet Res, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden rg Lab Diabet Res, Gothenburg, Sweden
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
, , anno: 2001, supplemento:, 121
pagine: 13 - 18
SICI:
1368-5031(200109):<13:PMOA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDIABETIC AGENT PIOGLITAZONE; WISTAR FATTY RATS; INDUCED INSULIN-RESISTANCE; ACTIVATED RECEPTOR PPAR; HEPATIC GLUCOSE OUTPUT; ADIPOCYTE DIFFERENTIATION; ANTIHYPERGLYCEMIC AGENT; PERIPHERAL INSULIN; DIABETES-MELLITUS; 3T3-F442A CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, U Univ Gothenburg, Dept Internal Med, Lundberg Lab Diabet Res, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden abet Res, Gothenburg, Sweden
Citazione:
U. Smith, "Pioglitazone: mechanism of action", INT J CL PR, 2001, pp. 13-18

Abstract

Thiazolidinediones, such as pioglitazone, are synthetic ligands for peroxisome proliferator-activated receptors (PPARs). They after the transcriptionof genes influencing carbohydrate and lipid metabolism, resulting in changed amounts of protein synthesis and, therefore, metabolic changes. Pioglitazone improves glycaemic control in people with Type 2 diabetes by improvinginsulin sensitivity through its action at PPAR gamma1 and PPAR gamma2, andaffects lipid metabolism through action at PPAR alpha. The results of these interactions include increases in glucose transporters 1 and 4, lowered free fatty acids, enhanced insulin signalling, reduced tumour necrosis factor alpha (TNF alpha) and remodelling of adipose tissue. Together, these can increase glucose uptake and utilisation in the peripheral organs and decrease gluconeogenesis in the liver, thereby reducing insulin resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:37:26