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Titolo:
Mechanisms of tissue damage in the postprandial state
Autore:
Ceriello, A;
Indirizzi:
Univ Udine, Dept Internal Med, I-33100 Udine, Italy Univ Udine Udine Italy I-33100 , Dept Internal Med, I-33100 Udine, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
, , anno: 2001, supplemento:, 123
pagine: 7 - 12
SICI:
1368-5031(200109):<7:MOTDIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE STRESS; DIABETIC-PATIENTS; NITRIC-OXIDE; HYPERGLYCEMIA; GLUCOSE; GENERATION; DIET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Ceriello, A Univ Udine, Dept Internal Med, I-33100 Udine, Italy Univ Udine Udine Italy I-33100 nal Med, I-33100 Udine, Italy
Citazione:
A. Ceriello, "Mechanisms of tissue damage in the postprandial state", INT J CL PR, 2001, pp. 7-12

Abstract

There is increasing evidence that the postprandial state is an important contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterised by a rapid and large increase in blood glucose levels and the possibility that the postprandial hyperglycaemic peaks may be relevant to the pathophysiology of late diabetic complications has recently received much attention. The oral glucose tolerance test, although highly non-physiological, has commonly been used as the model of the postprandial state. Epidemiological studies have shown that, when impaired, oral glucose tolerance is associated with an increased risk of cardiovasculardisease, with the glycaemia two hours after the glucose challenge a directand independent risk factor. Moreover, the possibility that postprandial hyperglycaemia is also a risk factor for cardiovascular disease in diabetic patients has been reported. Most of the cardiovascular risk factors are modified in the postprandial phase in patients with diabetes and are directly affected by an acute increase in glycaemia. The mechanisms through which acute hyperglycaemia exerts its effects may be identified as labile non-enzymatic glycation and production of free radicals. It is likely that the two mechanisms co-operate in causing the disorders induced by acute hyperglycaemia. Correcting the postprandial hyperglycaemia can form part of the strategy for the prevention and management of cardiovascular disease in diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:46:54